sting agonist-12

STING-IN-12 (compound Y2) acts as an inhibitor of STING. It suppresses IFNβ gene expression induced by SR717 with an IC50 of 0.75 μM. Additionally, STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and by MSA-2 in mice.

STING agonist-22 (CAS No. 2408723-12-4) is a synthetic, non-nucleotide small molecule activator of the Stimulator of Interferon Genes (STING) pathway, which is a critical component of the innate immune response to cytosolic DNA; STING agonist-22 is employed as a potent adjuvant to enhance the immunogenicity and effectiveness of vaccines by stimulating a robust, long-lasting, and broad-spectrum immune response through the induction of type I interferons and other cytokines.

STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.