sin10

Molsidomine (Corvaton) is an orally active, long-acting vasodilating drug. It metabolizes in the liver to the active metabolite linsidomine, that releases nitric oxide (NO) upon decay as the actual vasodilating compound.

FOBISIN101 is a novel inhibitor of all 14-3-3 isoforms in 14-3-3 PPIs.

c-Fms-IN-10, a derivative of thieno [3,2-d] pyrimidine, is a kinase inhibitor of FMS (Colony-stimulating factor-1 receptor, CSF-1R; IC50: 2 nM) with anti-tumor activity.

Pan-KRAS-IN-10 (Compound 58) acts as an inhibitor of the human tumor mutant gene KRAS. It suppresses the proliferation of KRAS mutant cells, specifically AsPC-1 (G12D mutant) and SW480 (G12V mutant), with IC50 values of 0.7 and 0.24 nM, respectively.

Orazipone inhibits cytokine production and histamine release; an NSAID.

Beta-defensin 103 isoform X1, pig, is an antimicrobial peptide found in various organisms, essential for the initial defense mechanisms of the innate immune system against pathogens [1].

Beta-defensin 103 isoform X1, pig TFA, is an antimicrobial peptide found in various living organisms, crucial for the initial defense of the innate immune system against pathogens [1].

Ferroptosis-IN-10 (compound D1) is an inhibitor of ferroptosis, demonstrating a potent IC50 value of 22 nM. It exhibits neuroprotective activity in the oxygen-glucose deprivation/reoxygenation (OGD/R) model.