s107

S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

S107 hydrochloride, a RyR-selective 1,4-benzothiazepine derivative, could stabilize RyR2 channels via enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.

Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.

IACS-010759 hydrochloride is an orally potent and selective OXPHOS inhibitor that inhibits proliferation and induces apoptosis in OXPHOS-dependent brain cancer and acute myeloid leukaemia models for the study of relapsed/refractory AML and advanced solid tumours.

IACS-010759 is an orally bioavailable inhibitor of complex I of oxidative phosphorylation of the mitochondrial electron transport chain.