rifampicin

Rifampicin (Rifamycin AMP) is a broad-spectrum antibiotic. Rifampicin has a strong antibacterial effect against Mycobacterium tuberculosis and is also effective against gram-positive and gram-negative bacteria and viruses.

25-Desacetyl rifampicin is a major active metabolite of the rifamycin antibiotic rifampicin .125-Desacetyl rifampicin is active againstM. smegmatis(MIC99= 2.66 μM). 1.Kigondu, E.M., Njoroge, M., Singh, K., et al.Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolitesMed. Chem. Commun.5502-506(2014)

Dmb-rifampicin is an inhibitor of nucleic acid polymerases.

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad-spectrum imidazole derivative with antifungal activity. Likely inhibiting cytochrome P450-dependent demethylation of lanosterol, it prevents ergosterol synthesis, a crucial component of the fungal cell membrane. This disruption of membrane synthesis and integrity alters permeability, promotes loss of essential intracellular components, and inhibits fungal cell growth.

Rifampin-BSA is a hapten-carrier protein conjugate formed by binding Rifampin to BSA (bovine serum albumin). It enhances Rifampin-induced immune responses by combining a hapten with a protein adjuvant, commonly used in vaccine or antibody preparation studies.

25-Desacetyl Rifampicin (Standard) is a reference standard for research and analysis in studies involving 25-Desacetyl Rifampicin. 25-Desacetyl rifampicin is a major active metabolite of the rifamycin antibiotic rifampicin .125-Desacetyl rifampicin is active againstM. smegmatis(MIC99= 2.66 μM).

Rifampicin-d3 is a deuterated compound of Rifampicin. Rifampicin has a CAS number of 13292-46-1. Rifampicin is an antibacterial drug of the class of rifamycin.

Rifampicin-d4 is a deuterated compound of Rifampicin.

Rifampicin-d8 is a deuterium-labelled compound of rifampicin, which can be used for isotope tracing. Rifampicin is a broad-spectrum antibiotic that primarily exerts its antibacterial activity by inhibiting bacterial DNA-dependent RNA polymerase.

Rifampicin (Standard) is the standard substance of Rifampicin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Rifampicin (Rifamycin AMP) is a broad-spectrum antibiotic. Rifampicin has a strong antibacterial effect against Mycobacterium tuberculosis and is also effective against gram-positive and gram-negative bacteria and viruses.

Rifampicin-13C-d3 the 13C and deuterated compound of Rifampicin. Rifampicin has a CAS number of 13292-46-1. Rifampicin is an antibacterial drug of the class of rifamycin.

Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.

Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytryptamine or [3H]dopamine in vitro. It blocked the inhibitory effects of rifampicin and tetraphenyl in classical behavioral tests using monoamine-depleted animals.

3-Formyl rifamycin is a degradation product of Rifampicin, with antibacterial activity.

Isobutyl Butyrate is a butyrate ester formed by the condensation of butyric acid with isobutyl alcohol, which is a metabolite of rifampicin, an antibiotic of rifamycins.Isobutyl Butyrate is a fruity organic compound used mainly in the formulation of flavors.

JSF-4898 is an orally bioactive inhibitor of Mycobacterium tuberculosis MenG enzyme. It exhibits a minimum inhibitory concentration (MIC) of 0.78 μM against Mycobacterium tuberculosis H37Rv. Additionally, JSF-4898 enhances the efficacy of rifampicin in a subacute infection model of Mycobacterium tuberculosis in mice.

MI891 is a highly selective PXR antagonist (IC50= 3.76 μM, Kd= 1.7 μM) and inverse agonist (IC50= 6.1 μM). It selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin-induced PXR activation and can be utilized in research on metabolic and other diseases.

NADH-IN-3 (Compound C4-1) is an NADH inhibitor with a minimum inhibitory concentration (MIC) of 4 μg/mL (13.042 μM) against the type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). It effectively blocks ATP synthesis and demonstrates potent inhibitory effects on both single-drug (Rifampicin and Isoniazid) and multidrug-resistant (Mtb) strains, exhibiting antibacterial activity while maintaining low cytotoxicity towards HepG2 cells (SI: 16.52).

MRL-436 is an RNA polymerase inhibitor with antibacterial activity. Its effectiveness depends on the β' subunit and the 622nd residue of the RNAP ω subunit. MRL-436 can inhibit Rifampicin-resistant RNA polymerase derivatives and shows antibacterial activity against Rifampicin-resistant strains.

SpHistin, an antimicrobial peptide (AMP), binds to lipopolysaccharide (LPS) and permeabilizes the bacterial membrane. In combination with Rifampicin and Azithromycin, it facilitates increased intracellular uptake of these antibiotics, thereby enhancing their collective bactericidal efficacy against Pseudomonas aeruginosa [1].

K11, an antimicrobial peptide, demonstrates activity against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL) and inhibits bacterial biofilm formation. It also acts synergistically with various antibiotics (Chloramphenicol, Meropenem, Rifampicin, etc.) to combat drug-resistant K. pneumoniae and exhibits high thermal and wide pH stability [1].

GmhA-IN-1 (compound 17), with an IC 50 of 2.4 nM, acts as an inhibitor of GmhA. It also boosts the effectiveness of erythromycin and rifampicin against wild-type E. coli [1].