rifampicin

Rifampicin (Rifamycin AMP) is a broad-spectrum antibiotic. Rifampicin has a strong antibacterial effect against Mycobacterium tuberculosis and is also effective against gram-positive and gram-negative bacteria and viruses.

25-Desacetyl rifampicin is a major active metabolite of the rifamycin antibiotic rifampicin .125-Desacetyl rifampicin is active againstM. smegmatis(MIC99= 2.66 μM). 1.Kigondu, E.M., Njoroge, M., Singh, K., et al.Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolitesMed. Chem. Commun.5502-506(2014)

Dmb-rifampicin is an inhibitor of nucleic acid polymerases.

Rifampicin-13C-d3 the 13C and deuterated compound of Rifampicin. Rifampicin has a CAS number of 13292-46-1. Rifampicin is an antibacterial drug of the class of rifamycin.

Rifampicin-d3 is a deuterated compound of Rifampicin. Rifampicin has a CAS number of 13292-46-1. Rifampicin is an antibacterial drug of the class of rifamycin.

Rifampicin-d4 is a deuterated compound of Rifampicin.

Rifampicin-d8 is a deuterated compound of Rifampicin. Rifampicin has a CAS number of 13292-46-1. Rifampicin is an antibacterial drug of the class of rifamycin.

Fezolamine is a novel orally available non-tricyclic compound with antidepressant activity. It is three to two times more selective in blocking synaptosomal uptake of [3H]norepinephrine than uptake of [4H]3-hydroxytryptamine or [3H]dopamine in vitro. It blocked the inhibitory effects of rifampicin and tetraphenyl in classical behavioral tests using monoamine-depleted animals.

3-Formyl rifamycin is a degradation product of Rifampicin, with antibacterial activity.

Isobutyl Butyrate is a butyrate ester formed by the condensation of butyric acid with isobutyl alcohol, which is a metabolite of rifampicin, an antibiotic of rifamycins.Isobutyl Butyrate is a fruity organic compound used mainly in the formulation of flavors.

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad-spectrum imidazole derivative with antifungal activity. Likely inhibiting cytochrome P450-dependent demethylation of lanosterol, it prevents ergosterol synthesis, a crucial component of the fungal cell membrane. This disruption of membrane synthesis and integrity alters permeability, promotes loss of essential intracellular components, and inhibits fungal cell growth.

SpHistin, an antimicrobial peptide (AMP), binds to lipopolysaccharide (LPS) and permeabilizes the bacterial membrane. In combination with Rifampicin and Azithromycin, it facilitates increased intracellular uptake of these antibiotics, thereby enhancing their collective bactericidal efficacy against Pseudomonas aeruginosa [1].

K11, an antimicrobial peptide, demonstrates activity against MDR XDR K. pneumoniae isolates (MIC: 8-512 μg mL) and inhibits bacterial biofilm formation. It also acts synergistically with various antibiotics (Chloramphenicol, Meropenem, Rifampicin, etc.) to combat drug-resistant K. pneumoniae and exhibits high thermal and wide pH stability [1].

GmhA-IN-1 (compound 17), with an IC 50 of 2.4 nM, acts as an inhibitor of GmhA. It also boosts the effectiveness of erythromycin and rifampicin against wild-type E. coli [1].