rgd-1563191

TIGIT Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.02 kDa and the accession number is XP_008766987.1.

Expression system: HEK293 Cells
Length: 1-141, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: BLI、ELISA

TIGIT Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.2 kDa and the accession number is A0A7N9I9V4.

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

TIGIT Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 16.01 kDa and the accession number is NP_001139797.1.

TIGIT Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.2 kDa and the accession number is NP_001139797.1.

TIGIT Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 39.93 kDa and the accession number is NP_001139797.1.

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA

TIGIT Protein, Human, Recombinant (aa 22-141, His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 14.51 kDa and the accession number is NP_776160.2.

T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.

Expression system: HEK293 Cells
Length: 1-141, Extracellular Domain
Activity: ELISA