repeats

DNL343 is a selective and potent eIF2B activator that crosses the blood-brain barrier and inhibits the assembly of stress granules (SGs) induced by the C9ORF72 dipeptide repeats. DNL343 may be useful in the study of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS).

UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2 3.1 uM for L3MBTL1 3.

NSC66098 is a novel potent inhibitor of Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein.

SPEN-IN-1 (compound X1) is a selective inhibitor of the SPEN protein factor, with a dissociation constant (K d) of 47 nM. It specifically targets RepA, a 431-nucleotide domain within Xist (a non-coding RNA prototype), characterized by 8.5 repeats of a GC-rich motif instrumental in gene silencing [1].

ORN 06 (Compound R-0006) is a U-rich single-stranded RNA containing 6 repeats of the UUG sequence motif, and it functions as a TLR7 8 agonist. This compound stimulates human TLR7 8-mediated or murine TLR7-mediated immunity [1].

GSK_WRN2 is a potent, selective covalent inhibitor of the WRN helicase, which targets replication stress caused by the amplification of DNA (TA)n dinucleotide repeats. It can be utilized in research focusing on microsatellite instability (MSI) cancers.

Lipopolysaccharides (LPS) are specific endotoxins that serve as a major component of the cell walls in gram-negative bacteria. Composed of Lipid A, a core oligosaccharide, and an O-specific polysaccharide, LPS strongly stimulates the immune system by binding to Toll-like receptor 4 (TLR4) on immune cells, triggering inflammatory responses. In most Salmonella serotypes, the LPS features a complex O-antigen (OAg) structure, with core oligosaccharide OAg units ranging from 16 to over 100 repeats. Mutations in OAg regulatory factors can alter the OAg structure, affecting Salmonella interactions with epithelial cells. Strains with long OAgs show increased translocation and invasion by SPI1-T3SS effector proteins, while strains lacking OAg entirely exhibit increased invasiveness and adhesion. This product is derived from Salmonella enterica serotype minnesota and is utilized for studies on host immune activation and its roles in inflammation and immune modulation.