pyrimidine

Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and thymidine respectively), or deoxyribose-containing deoxynucleosides, and their corresponding ribonucleotides or deoxyribonucleotides. Pyrimidines serve essential functions in human metabolism as ribonucleotide bases in RNA (uracil and cytosine), and as deoxyribonucleotide bases in DNA (cytosine and thymine), and are linked by phosphodiester bridges to purine nucleotides in double-stranded DNA, in both the nucleus and the mitochondria. Pyrimidine activated sugars are also involved in polysaccharide and phospholipid synthesis, glucuronidation in detoxification processes, glycosylation of proteins and lipids and in the recently identified novel endothelium-derived vasoactive dinucleotides.

Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.

Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.

Ecamsule is a benzylidene camphor derivative, many of which are known for their excellent photostability. It can be added to many sunscreens to filter out UVA rays.

Sorivudine (BV-araU) has antiviral activity against several viruses including varicella zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus by interfering with viral DNA synthesis.

Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.

EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.

Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.

Deoxycytidine triphosphate is a nucleoside triphosphate.It is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.

Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).

4,6-Dichloro-2-(methylthio)pyrimidine ,with CAS No. 6299-25-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4,6-Dichloro-2-(methylthio)pyrimidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7-ketopyrazolo(4,3-d)pyrimidine, with CAS No. 13877-55-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-ketopyrazolo(4,3-d)pyrimidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7-Chloro-5-methyl-2-(4-methylphenyl)[1,2,4]triazolo[1,5-a]pyrimidine is a chemical intermediate that can be used to synthesize benzopyrimidine thioethers.

Thieno[3,2-d]pyrimidine, 4-methoxy-7-methyl- ,with CAS No. 676549-71-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Thieno[3,2-d]pyrimidine, 4-methoxy-7-methyl- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Thieno[2,3-d]pyrimidine, 4-methoxy-5-methyl- ,with CAS No. 19673-95-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Thieno[2,3-d]pyrimidine, 4-methoxy-5-methyl- provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-Methylthio-4-pyridin-3-yl-pyrimidine ,with CAS No. 637354-24-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Methylthio-4-pyridin-3-yl-pyrimidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-7-carboxylic acid, with CAS No. 1245569-58-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-7-carboxylic acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-(pentylsulfanyl)pyrimidine-4,6-diol is a novel GRP84 agonist.

2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid is commonly used to synthesize compounds with anticancer and antitumor properties.

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE used for preparation of pyrimidopyrimidines as protein kinase inhibitors.

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine ,with CAS No. 3680-69-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is an inhibitor of the enzyme phosphodiesterase 10A (PDE10A) with a Ki value of 24 μM. This compound can be employed in research related to schizophrenia.

Pyrazolo[1,5-a]pyrimidine 4h is a morpholine derivative that is a selective antagonist of the adenosine A2A receptor. It has been shown to be neuroprotective in animal models of Parkinson's disease and Huntington's chorea.

(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.