purine bases

2-Fluoroadenine (NSC-27364) has toxicity in nonproliferating and proliferating tumor cells. 2-Fluoroadenine can be used for anticancer studies.

Adenine is a purine-derived nucleobase and one of the four bases of DNA. It is an important chemical component of both DNA and RNA, involved in cellular respiration, the formation of ATP and coenzymes NAD and FAD, as well as protein synthesis. Adenine is commonly used to induce chronic kidney injury models.

Pyrimidine (Metadiazine)s are heterocyclic, six-membered, nitrogen-containing carbon ring structures, with uracil, cytosine and thymine being the basal structures of ribose-containing nucleosides (uridine, cytidine, and thymidine respectively), or deoxyribose-containing deoxynucleosides, and their corresponding ribonucleotides or deoxyribonucleotides. Pyrimidines serve essential functions in human metabolism as ribonucleotide bases in RNA (uracil and cytosine), and as deoxyribonucleotide bases in DNA (cytosine and thymine), and are linked by phosphodiester bridges to purine nucleotides in double-stranded DNA, in both the nucleus and the mitochondria. Pyrimidine activated sugars are also involved in polysaccharide and phospholipid synthesis, glucuronidation in detoxification processes, glycosylation of proteins and lipids and in the recently identified novel endothelium-derived vasoactive dinucleotides.

5-Methyluridine (Thymine riboside) is an endogenous methylated nucleoside found in human fluids; methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls.DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents.

Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide resulting from the deamination of purine bases, is essential in various biological processes.

Purine (7H-Imidazo(4,5-d)pyrimidine) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Two of the bases in nucleic acids, adenine and guanine, are purines. Purines from food (or from tissue turnover) are metabolised by several enzymes, including xanthine oxidase, into uric acid. High levels of uric acid can predispose to gout when the acid crystalises in joints; this phenomenon only happens in humans and some animal species (e.g. dogs) that lack an intrinsic uricase enzyme that can further degrade uric acid.

Ap4C tetrasodium is a dinucleotide polyphosphate that includes both purine and pyrimidine bases. This compound functions as a signaling molecule by interacting with specific P2Y receptors. It activates P2Y2 and P2Y4 receptors in platelets, inducing platelet aggregation and other cellular responses. Ap4C tetrasodium is utilized in studies related to inflammation and blood coagulation.

5-Aminoimidazole ribonucleotide sodium (AIR) is an intermediate in purine biosynthesis. It undergoes further enzymatic modification to eventually form inosine monophosphate (IMP), which can then be converted into the purine bases adenine (A) and guanine (G). 5-Aminoimidazole ribonucleotide sodium is considered an endogenous metabolite (endogenous metabolite).

5-Aminoimidazole ribonucleotide (AIR) serves as an intermediate in purine biosynthesis, undergoing enzymatic modifications to form inosine monophosphate (IMP), which is subsequently converted into the purine bases adenine (A) and guanine (G) [1].

N-1H-imidazo[4,5d ]pyridazin-7-yl benzamideN4-Benzoyl-2-aza-3'-deazaadenine is a Heterocyclic Compound - Purine; Intermediates and Building Blocks - Nucleoside bases.

Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).