ptdins(4)p

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt) is a synthetic analogue of natural PtdIns, featuring C6:0 fatty acids at the sn-1 and sn-2 positions.

PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (DOPI-3,4,5-P3) sodium is an analog of phosphatidylinositol.

PtdIns-(3,4)-P2 (1,2-dipalmitoyl) (PI(3,4)P2 (16:0/16:0)) sodium is a phosphatidylinositol.

PtdIns-(3,4,5)-P3-(1-stearoyl, 2-arachidonoyl) sodium is a specific molecular form of phosphatidylinositol-3,4,5-triphosphate (PIP3). As a core lipid messenger in the tyrosine kinase pathway, PIP3 regulates cell proliferation, survival, and metabolism by recruiting effector proteins, with abnormalities linked to cancer. PtdIns-(3,4,5)-P3-(1-stearoyl, 2-arachidonoyl) sodium is utilized in lipid signaling research.