ptdins(4)p

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt) is a synthetic analogue of natural PtdIns, featuring C6:0 fatty acids at the sn-1 and sn-2 positions.

PtdIns-(3,4,5)-P3 (1,2-dioctanoyl) (DOPI-3,4,5-P3) sodium is an analog of phosphatidylinositol.