protozoan

Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections in poultry, cattle, swine and farmed fish until suspected to be carcinogenic and mutagenic to humans. Hydroxy dimetridazole is a metabolite of dimetridazole that may be useful for identifying this nitroimidazole in various agricultural samples through liquid chromatography-tandem mass spectrometry and other methods.

Dichlorophen (DDM) is a nontoxic laxative vermicide of chlorinated phenol compound. Dichlorophen is used as a veterinary fungicide, anthelmintic, and anti-protozoan, as well as an ingredient in antimicrobial soaps and shampoos. This agent probably acts by increasing the clearing of intestinal contents, thereby eradicating tapeworm infections from the intestines.

Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) is a drug that combats protozoan infections. It is a nitroimidazole class drug. It has been banned by the Canadian government as a livestock feed additive.

Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Chloramphenicol acts primarily on the 50S subunit of the bacterial 70S ribosome and is active against peptidyltransferases, inhibiting the formation of peptide bonds.

β-Ocimene, a volatile substance released in large quantities from the leaves and flowers of many plant species, is a multifaceted attractant for a wide range of pollinators, possesses antileishmanial protozoan activity, and inhibits the growth of M. persicae.

Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.

L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 µM for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response

Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively.

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1O-11 exhibits essentially no anti-fungal activity when assayed usingC. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)

4-Amino-L-phenylalanine (4APhe) is a TcCA activator, useful for studying protozoan pathogen infections.

GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation. GW837016X extended life of treated mice by 50%, compared to untreated controls. At the cellular level, GW837016X inhibited mitosis and cytokinesis in T. brucei.

NEU617 is an inhibitor of the growth of protozoan parasites, against T. brucei bloodstream proliferation.

PF00349412 is a selective inhibitor of protozoan protein N-myristoyltransferases. Inhibition of N-myristoyltransferase has been validated pre-clin. as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors.

FFK29 is a synthetic class II HDACi (Histone deacetylase inhibitors) which have have recently emerged as novel therapeutic options for treating various protozoan and parasitic diseases. While these HDACi demonstrated a negligible effect on the viability of mature cysts, Acanthamoeba encystation was significantly inhibited by these HDACi. In conclusion, these synthetic HDACi demonstrated potent amoebicidal effects and inhibited the growth and encystation of Acanthamoeba, thus highlighting their enormous potential for further development.

Imidocarb dipropionate is an antigenic insecticide, is active against the protozoan parasite B. bovis (IC50 : 0.87 µg ml).

ELQ-596, a quinolone derivative, exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-596 attenuates babesiosis in immunosuppressed mice [1].

ELQ-650, a quinolone derivative, exhibits antimicrobial activity against several protozoan parasites, including intraerythrocytic Plasmodium and Babesia, and attenuates babesiosis in immunosuppressed mice [1].

Hydroxy Dimetridazole-d3 is a deuterated compound of Hydroxy Dimetridazole. Hydroxy Dimetridazole has a CAS number of 936-05-0. Hydroxy Dimetridazole is a hydroxy metabolite of Dimetridazole which combats protozoan infections.

Dimetridazole-d3 is a deuterated compound of Dimetridazole. Dimetridazole has a CAS number of 551-92-8. Dimetridazole is a drug that combats protozoan infections. It is a nitroimidazole class drug. It has been banned by the Canadian government as a livestock feed additive.