propafenone

Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.

Propafenone-d5 HCl is a deuterated compound of Propafenone HCl. Propafenone HCl has a CAS number of 34183-22-7. Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.

5-Hydroxy Propafenone D5 HCl is the deuterium labeled 5-Hydroxy Propafenone.

5-Hydroxy Propafenone-d5 HCl is a deuterated compound of 5-Hydroxy Propafenone HCl.

(S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone, exhibiting beta-blocking properties and class 1 antiarrhythmic activity through sodium channel blockade.

Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.

LG 6-102 is a propafenone-related antiarrhythmic compound with good oral activity in rats.

GPV574, a derivative of the antiarrhythmic compound propafenone, inhibits the HERG channel (IC50 = 5.04 μM).

LG 6-101 is a propafenone-related antiarrhythmic compound with good oral activity in rats.