photoaffinity

YM 534 has antitumor activity and platelet aggregation activity, inhibits photoaffinity labeling of deglycosylated P-glycoprotein, and can be used to study leukemia.

Benzoylphenylalanine (LBPA) can be used as a photoaffinity peptide inactivator.

PARPYnD is a potent photoaffinity probe for poly(ADP-ribose) polymerase (PARP) (IC50 values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). PARPYnD labels PARP1 and PARP2 in the cell when an N3 functionalized fluorescent probe is attached and can inhibit isolated PARP6.

Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.

4-Azido-L-phenylalanine (p-Azido-L-phenylalanine) is an amino acid derivative that acts as a photoaffinity marker and can be used to detect localized protein environments.

GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).

L 669083 is two classes of potent leukotriene biosynthesis inhibitors photoaffinity analogue.

L458-BPyne is a γ-secretase modulator photoaffinity probe that acts by identifying distinct allosteric binding sites on presenilin. It also can be exploited to reduce levels of pathogenic Aβ species.

RO-57-Bpyne is a γ-secretase modulator photoaffinity probe. It also can be exploited to reduce levels of pathogenic Aβ species. It acts by identifying distinct allosteric binding sites on presenilin.

163-bp3 is an effective photoaffinity probe and can be used as a target γ Secretory enzyme.

BI-RJ 70 is a tritiated photoaffinity azide analog of nevirapine, which can be used to study the binding of nevirapine to HIV-1 transcriptase through covalently labeled enzymes and amino acid residues.

CGP 55802A is a novel photoaffinity ligand for in-situ labeling of NMDA receptors.

LU 49888 is a photoaffinity analog of verapamil that has been used to identify specific binding sites for phenylalkylamines of calcium channels present in rabbit skeletal muscle microsomes.

2,6-Dichloropurine-9-β-D-riboside is a building block.1,2It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins. 1.Wower, J., Hixson, S.S., Sylvers, L.A., et al.Synthesis of 2,6-diazido-9-(β-D-ribofuranosyl)purine 3',5'-bisphosphate: Incorporation into transfer RNA and photochemical labeling of Escherichia coli ribosomesBioconjug. Chem.5(2)158-161(1994) 2.Seiter, M.S., Bauer, M.P., Bogel, P.D., et al.Synthesis of novel spin-labeled photoaffinity derivatives of NAD+ and ATP and their characterization as coenzymes and substrates of several enzymesSynthesis2269-273(1996)

Azidothiorphan is a photoaffinity ligand for the active site of the neutral endopeptidase 24.11. After ultraviolet irradiation the inhibitor binds irreversibly to the enzyme, and photolabeling occurs at the active site. The competitive inhibitor thiorphan protects the endopeptidase from inactivation.

Antibacterial agent 116, a benzophenone-containing salicylanilide compound, exhibits potent antibacterial activity by inhibiting peptidoglycan formation. It is employed as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), thereby blocking the propagation pathway and disrupting the growth of the peptidoglycan chain.

Fmoc-L-photo-proline is an amino acid capable of photo-crosslinking, designed for incorporation into synthetic peptides through solid-phase Fmoc chemistry. It facilitates the synthesis of cyclic peptidomimetic antibiotics and is utilized in the preparation of a wide array of peptide-based photoaffinity probes for research purposes [1].

4-Azido-2,3,5,6-tetrafluorobenzoic Acid (N3-TFBA) serves both as a click chemistry reagent with an azide group and as a complex with FAM-labeled DNA probe. This compound is also employed as a versatile photoaffinity labeling agent for probing biological receptors.

Fmoc-L-Lys(4-N3-Z)-OH is a chemical reagent characterized by its azide group. This compound serves as a lysine building block in solid-phase peptide synthesis (SPPS) with azide functionality, useful as a bioorthogonal handle, an infrared probe, and a photoaffinity label. It undergoes strain-promoted 1,3-dipolar cycloaddition facilitated by trans-cyclooctene decarboxylation. Additionally, Fmoc-L-Lys(4-N3-Z)-OH functions as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. Moreover, it can participate in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules that possess DBCO or BCN groups.

Nph-peptide can be used for photoaffinity labeling of the N-formyl peptide receptor site of intact human polymorphonuclear leukocytes.