phosphatidylserine

Phosphatidylserines sodium salt (L-α-Phosphatidylserine sodium salt) is a compound extracted from natural soybean oil residues. It is an active substance present in cell membranes, which can improve nerve cell function and can be used to study nervous system diseases.

DSPS (Dioctadecanoylphosphatidylserine) is a glycerophospholipid, an important phospholipid membrane component that plays a key role in cell cycle signaling. DSPS can regulate cellular activity and mediate apoptosis. DSPS is widely used as a nutritional supplement.

Phosphatidylserine is a phospholipid naturally present in mammals, exhibiting anti-inflammatory and anti-atherosclerotic effects. It activates PKC, neutral sphingolipidase, C-raf-1 protein kinase, and other cofactors involved in multiple signaling pathway activations.

Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.

Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.

Dioleoyl phosphatidylserine is a lipid under investigation, primarily used to study the assembly and long-term stability of solid-supported lipid bilayers formed from artificial and natural lipid mixtures.

Distearoylphosphatidylserine sodium is an anionic phospholipid with stearic acid tails (18:0), featuring a head group that contains both a carboxylic acid (COOH) and an amine (NH2). It is used in the preparation of mixed lipid vesicles, liposomes, or artificial membranes.

Distearoylphosphatidylserine-d70 (sodium) is the deuterated form of (S)-2-amino-2-carboxyethyl ((R)-2,3-bis(stearoyloxy)propyl) phosphate.

18:0-LPS (Lysophosphatidylserine C18:0) is an endogenous lipid identified during the oxidation of phospholipids. It holds potential for use in cardiovascular disease research.

Hexadecylphosphoserine is a type of phospholipid molecule that incorporates a long-chain alkyl group (hexadecyl) and a phosphatidylserine group, granting it high affinity for cell membranes. This compound exhibits antitumor activity by modulating [Ca++]i and related signaling pathways, making it useful for breast cancer research.

TBPH exacerbates liver steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It induces phospholipid metabolism disorders, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH causes lung injury through mitochondrial-derived ds-DNA-mediated inflammatory responses. TBPH is utilized to study the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.

Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes. 1.López-Martín, C., Pérez-Victoria, J.M., Carvalho, L., et al.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomesAntimicrob. Agents Chemother.52(11)4030-4036(2008) 2.Carvalho, L.J.M., Luque-Ortega, J.R., López-Martín, C., et al.The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenaseAntimicrob. Agents Chemother.55(9)4204-4210(2011)

Phosphatidylethanolamine (PE) contains phospholipids found in mammals, formed by decarboxylation of phosphatidylserine.

Sodium 18:0,22:6 phosphatidylserine (PS) is a lipid found within synaptic vesicles alongside cholesterol, utilized in metabolic research [1].

Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody targeting phosphatidylserine (PS) with vascular targeting and immunomodulatory properties, capable of reactivating anti-tumor immunity to inhibit tumor growth. It has anti-cancer activity and is frequently used with Paclitaxel and Carboplatin in non-small cell lung cancer studies.

PhosTAC7 successfully induced ternary protein complex formation and dephosphorylation of phosphatidylserine 318 (pS318) by Halo-FOXO3a in a dose-dependent manner.

N-myristoyl-RKRTLRRL is a compound that impedes the binding of protein kinase C (PKC) substrates and inhibits calcium (Ca2+)- and phosphatidylserine (PS)-dependent phosphorylation of histones, exhibiting an IC50 of 5 μM. Additionally, it demonstrates an inhibitory effect on histone phosphorylation with an IC50 of 80 μM [1] [2].

DS55980254 is a highly effective and specific inhibitor of phosphatidylserine synthase 1 (PTDSS1) [1].

M6903 is a humanized IgG2 monoclonal antibody that targets T-cell immunoglobulin and mucin domain 3 (TIM-3), with a binding affinity (KD) of 2.3 nM for human TIM-3. By binding to TIM-3, M6903 blocks the interaction of TIM-3 with phosphatidylserine (PtdSer), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and galectin-9 (Gal-9). This blockade helps alleviate TIM-3-mediated T-cell inhibition, promoting antigen-specific T-cell activation and enhancing antitumor immunity. M6903 holds promise for cancer research.

DPPS (12-Dipalmitoyl-sn-glycero-3-PS sodium salt) is an anionic diacyl-phospholipid, a form of phosphatidylserine (PS), which is a negatively charged phospholipid located in the lobules of cell membranes. DPPS are used to make cationic vesicles and liposomes.

Pd-C-II has anti-inflammation activity, it can inhibit TNF-α production and iNOS protein expression and inhibit COX-2 protein expression in LPS-stimulated RAW 264.7 cells. Pd-C-II inhibits anaphylactic mediator release from purified mast cells induced by

MPSD (MARCKS-ED), a 25-amino acid peptide derived from the effector domain sequence of the myristoylated alanine-rich C-kinase substrate (MARCKS), possesses the ability to detect membrane curvature and identify phosphatidylserine. This compound is valuable as a biological probe for investigating membrane shape and lipid composition.

MPSDTFA (MARCKS-ED TFA) is the TFA salt form of MPSD. This compound is a peptide consisting of 25 amino acid residues derived from the effector domain sequence of the endoplasmic reticulum protein myristoylated alanine-rich C-kinase substrate (MARCKS). MPSD TFA is capable of sensing membrane curvature and recognizing phosphatidylserine. It serves as a biological probe for studying membrane morphology and lipid composition.

MPSDcontrol peptide (MARCKS-ED control peptide) serves as the counterpart for the MPSD peptide. MPSD (MARCKS-ED) is a 25-amino acid residue peptide derived from the effector domain sequence of the endoplasmic reticulum protein MARCKS. It can detect membrane curvature and identify phosphatidylserine, functioning as a biological probe for examining membrane morphology and lipid composition.