p 37

MPXV p37 protein-IN-1 is a potent and orally effective inhibitor of the monkeypox virus (MPXV) p37 protein. It exhibits significant antiviral activity against MPXV, with an EC50 of 12.14 nM, and shows low cytotoxicity (CC50= 304.63 μM). In mice, MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability. This compound can be utilized for research into anti-monkeypox virus drugs.

CP 375 is a Fe3+ chelating agent (log K1: 14.50).

CP 376395 (CP-316311) is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.

CAP 37 (20-44), a peptide derived from amino acid residues 20 to 44 of CAP37, embodies a segment of the cationic antimicrobial protein of 37 kDa. This multifunctional protein plays significant roles as indicated in its description [1].

CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents and also has antidepressant and anxiolytic properties.

Ursolic acid (Prunol) is a natural product, a pentacyclic triterpene carboxylic acid extracted from Rhododendron caprifolium. Ursolic acid has anti-tumor, anti-inflammatory, anti-bacterial and hypoglycemic activities.

CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.

CSLP37 is a selective RIPK2 inhibitor with an IC50 of 16.3 nM and demonstrates no inhibitory activity against RIPK1 or RIPK3. Additionally, CSLP37 effectively suppresses cellular responses mediated by NOD1 and NOD2.

Diethylcarbamazine, an anthelmintic, is used primarily as the citrate in the treatment of filariasis, particularly infestations with Loa loa or Wucheria bancrofti.

TGP-377 is a potent inhibitor of miR-377 that specifically and effectively enhances the expression of VEGFA by targeting the non-coding microRNA that regulates VEGFA expression.

Rabdosin C is an ent-kaurane diterpenoid natural product that can be isolated and extracted from Isodon rubescens var. lushanensis. Existing studies confirm that Rabdosin C exhibits certain cytotoxic activity.

CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).

CP 376395 hydrochloride is a potent and selective CRF-RI receptor antagonist.

HT-2157 (SNAP-37889) is a selective, high-affinity competitive antagonist of the galanin-3 receptor (Gal3), demonstrating effective inhibition of this target.

TGP-377/421 (Targapre-miR-377/421) is a potent dual inhibitor that binds to and inhibits miR-377 and miR-421 at their functional sites.

Desmethyl Erlotinib (CP-473420) is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).

Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.

'(Asp37)-Amyloid β-Protein (1-42) [1]' refers to the G37D mutant variant of the wild-type Amyloid-beta (1-42) peptide.

The Anti-CEACAM7 Antibody (P3-7B) is a chimeric monoclonal antibody of the mouse IgG1, κ class, targeting CEACAM7 (human origin). Its isotype control is MouseIgG1kappa, Isotype Control.

CEP-37248 is a human monoclonal antibody (mAb) targeting IL-12. It is utilized in Alzheimer's disease research.

Tyrosinase (369-377,YMDGTMSQV) is derived from the membrane protein tyrosinase by posttranslational conversion of the sequence YMNGTMSQV. Presentation of YMDGTMSQV in cells expressing full-length tyrosinase is TAP-(transporter associated with antigen proc

MPSDcontrol peptide (MARCKS-ED control peptide) TFA serves as the control peptide for MPSD. MPSD (MARCKS-ED) is a 25-amino acid peptide derived from the effector domain sequence of MARCKS, a myristoylated alanine-rich C kinase substrate, which is an intracellular membrane protein.

LARLLT TFA is an EGFR-binding peptide. LARLLT shows research potential for cancers with EGFR overexpression, such as lung cancer, ovarian cancer, and colorectal cancer.

INF7TAT-P55 (P55) is a peptide that facilitates the delivery of CRISPR-engineered ribonucleoproteins. It enables efficient genomic editing in T cells and is particularly effective for CD34+ hematopoietic stem and progenitor cells (HSPC).