outward current

Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.

5-Hydroxypropafenone, an active metabolite of propafenone, inhibits transient outward potassium current (Ito) in isolated human atrial myocytes with an IC50 of 1.5 µM. In vivo, it increases the atrial effective refractory period in dogs at doses of 0.5, 1, and 2 mg/kg.

Inactive analog of m-3M3FBS (PLC activator)

Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval.

Tityustoxin-Kα (TsTx-Kα) inhibits potassium voltage-gated channels, causing a dose-dependent blockade of the sustained outward current in cultured hippocampal neurons [1].