octanoyl coenzyme a

Octanoyl coenzyme A triammonium, a medium-chain acyl coenzyme A, can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC50 values of 0.4-1.6 mM [1].

Octanoyl coenzyme A lithium, a derivative of fatty acid acyl coenzyme A, inhibits citrate synthase and glutamate dehydrogenase (IC50: 0.4-1.6 mM).

Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.

1-Pyrenebutanoyl-CoA, a type of coenzyme A, can non-competitively inhibit (K i = 2 pM) phosphorylating (ADP-stimulated) respiration in rat liver mitochondria and competitively inhibit (K i = 2.1 pM and 15 pM) carnitine palmitoyl-CoA transferase and octanoyl-CoA transferase [1].