nimbolide

Nimbolide, a triterpenoid derived from neem leaves and flowers, is a natural product and a CDK4/CDK6/NF-κB inhibitor that inhibits multiple signaling pathways including Wnt and PI3K-Akt, possesses antitumor activity, and can induce tumor cell apoptosis.

28-Deoxonimbolide is a nimbolide-type limonoid natural product isolated from the seeds of Azadirachta indica. In vitro, it induces apoptosis in tumor cells (e.g., HL-60), with mechanisms involving mitochondrial pathways and potentially the participation of death receptor signaling. It is commonly used in studies of anticancer mechanisms.

2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in stomach (AZ521) cancer cell line.