neuralgia

SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.

GW-493838 is a potent adenosine A1A receptor agonist for the treatment of dyslipidemia and neuropathic pain, with analgesic effects on post-herpetic neuralgia or peripheral nerve damage caused by trauma or surgery.

ADL-5747 (ADL-5747 (free base)) (free base) is a delta opioid receptor agonist used in the treatment of neurological disorders, skin and musculoskeletal disorders, and may be used in the study of postherpetic neuralgia, knee osteoarthritis and pain.

Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not understood; however, carbamazepine is commonly used to treat pain associated with trigeminal neuralgia.

CPI1189 (REN-1189) is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.

Laflunimus (HR325) is a DHODH inhibitor that inhibits immunoglobulin IgM and IgG secretion in vitro and in vivo, with an IC50=2.5 μm, and exerts an immunosuppressive effect by interfering with pyrimidine metabolism, and is used in the study of neuralgia.

(S)-baclofen (also known as L-baclofen), an enantiomer of baclofen, directly mimics the action of GABA-B receptors. In the treatment of trigeminal neuralgia, L-baclofen demonstrates significantly improved efficacy compared to racemic baclofen.

AAK1-IN-10 (Compound 1-2) is an AAK1 inhibitor with significant enzymatic inhibition of AAK1 (IC50: 9.62 nM). Its primary mechanism involves inhibiting adaptor-associated kinase 1 (AAK1) activity. AAK1-IN-10 exhibits minimal cardiotoxicity (IC50 = 13.7 μM) and can be utilized in research for diabetic neuralgia and postherpetic neuralgia.

V-116517, a TRPV1 antagonist, is used potentially for the treatment of severe pain due to osteoarthritis and chronic pain due postherpetic neuralgia (PHN).

WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pain, inflammatory pain, and occipital neuralgia.

Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF (nerve growth factor). It inhibits the sensitisation and conduction of peripheral pain fibres by blocking the interaction between NGF and the p75 and TrkA receptors, thereby treating various acute and chronic pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.

Carbamazepine D4 is a deuterated isotope compound of carbamazepine. Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not understood; however, carbamazepine is commonly used to treat pain associated with trigeminal neuralgia.

Carbamazepine-D10 is a deuterated compound of Carbamazepine. Carbamazepine (T0943) has a CAS number of 298-46-4. Carbamazepine (T0943) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine (T0943) exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not understood; however, carbamazepine is commonly used to treat pain associated with trigeminal neuralgia.

Flupirtine-d6 (D 9998-d6) hydrochloride is a deuterium-labeled version of Flupirtine hydrochloride. This compound, known as Flupirtine hydrochloride (D 9998 hydrochloride), acts as a selective neuronal potassium channel opener and exhibits analgesic properties. It is utilized to alleviate various pain conditions, including chronic musculoskeletal pain, migraines, and neuralgia. Additionally, Flupirtine hydrochloride possesses antidepressant and antioxidant traits, enhancing the analgesic effects when used in combination with morphine. It effectively reduces abnormal muscle tension, providing muscle relaxation. Clinically, Flupirtine hydrochloride demonstrates superior tolerability regarding side effects compared to other medications such as tramadol and pentoxyverine. It significantly inhibits excessive neuronal excitability, showcasing its potential in moderating various pain states.

Carbamazepine (Standard) is the standard substance of Carbamazepine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not understood; however, carbamazepine is commonly used to treat pain associated with trigeminal neuralgia.

Carbamazepine-D10 (Standard) is a reference standard of Carbamazepine-D10 intended for quantitative analysis, quality control, and related biochemical research applications. Carbamazepine-d10 is a deuterated compound of Carbamazepine. Carbamazepine has a CAS number of 298-46-4. Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not understood; however, carbamazepine is commonly used to treat pain associated with trigeminal neuralgia.