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ADL-5747

Name: ADL-5747
Brand: TargetMol
SKU: T29663
Price: 143 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29663Cas No. 850176-30-6

Alias ADL-5747 free base, ADL-5747 (free base), ADL5747

ADL-5747 (ADL-5747 (free base)) (free base) is a delta opioid receptor agonist used in the treatment of neurological disorders, skin and musculoskeletal disorders, and may be used in the study of postherpetic neuralgia, knee osteoarthritis and pain.

ADL-5747

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Purity: 99.74%

Catalog No. T29663Alias ADL-5747 free base, ADL-5747 (free base), ADL5747Cas No. 850176-30-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$143	In Stock	In Stock
5 mg	$360	In Stock	In Stock
10 mg	$530	In Stock	In Stock
25 mg	$859	In Stock	In Stock
50 mg	$1,180	In Stock	In Stock
100 mg	$1,590	-	In Stock
500 mg	$3,190	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

ADL-5747 AI Summary

ADL-5747 shows bioactivities related to opioid receptor interactions, particularly with high affinity for the human delta opioid receptor, displaying both agonist activity and antihyperalgesic effects in rat inflammatory pain models. Additionally, it exhibits inhibition of various cytochrome P450 enzymes and ion channels, and demonstrates metabolic stability in liver microsomes. The compound has different sensitivities to CYP enzyme inhibition and shows evidence of systemic clearance, volume of distribution, oral bioavailability, and drug uptake in different animal models. Furthermore, its distribution coefficient, measured in an Octan-1-ol/water (pH7.4) system using a shake flask method, resulted in a LogD7.4 value of 0.77, indicating a moderate propensity to partition between octan-1-ol and water phases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ADL-5747 (ADL-5747 (free base)) (free base) is a delta opioid receptor agonist used in the treatment of neurological disorders, skin and musculoskeletal disorders, and may be used in the study of postherpetic neuralgia, knee osteoarthritis and pain.
Synonyms	ADL-5747 free base, ADL-5747 (free base), ADL5747

Chemical Properties

Molecular Weight	392.49
Formula	C₂₄H₂₈N₂O₃
Cas No.	850176-30-6
Smiles	OC1=C(C2=CC3(OC=4C2=CC=CC4)CCNCC3)C=CC(C(N(CC)CC)=O)=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (140.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5478 mL	12.7392 mL	25.4784 mL	127.3918 mL
5 mM	0.5096 mL	2.5478 mL	5.0957 mL	25.4784 mL
10 mM	0.2548 mL	1.2739 mL	2.5478 mL	12.7392 mL
20 mM	0.1274 mL	0.6370 mL	1.2739 mL	6.3696 mL
50 mM	0.0510 mL	0.2548 mL	0.5096 mL	2.5478 mL
100 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc