neoplastic disease

Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.

1. Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) has anti-inflammatory activity. 2. Ethyl trans-caffeate may as a promising natural compound for future application in chronic liver disease. 3. Ethyl trans-caffeate is a potent chemopreventive compound against skin carcinogenesis caused by solar UV exposure. 4. Ethyl trans-caffeate is the high-resolution structures of representative inhibitors in complex with human pancreatic α-amylase. 5. Ethyl trans-caffeate strongly inhibits neoplastic transformation of JB6 Cl41 cells without toxicity. PI3K, ERK1 2, and p38 kinase activities were suppressed by direct binding with HOEC in vitro.