mpo-in-1

MPO-IN-1 is an orally active myeloperoxidase (MPO) inhibitor, inhibiting MPO and thyroid peroxidase (TPO). It is useful in inflammation research.

SNT-8370 is an orally active inhibitor of VAP-1 (IC50: 10 nM) and myeloperoxidase (MPO) (IC50: 17 nM), exhibiting 100-1000 times greater inhibitory potency on VAP-1 and MPO compared to other mammalian peroxidases. It effectively suppresses MPO-mediated LDL lipid peroxidation and reduces leukocyte infiltration in acute inflammatory lung injury models. SNT-8370 is an anti-inflammatory compound suitable for research on inflammatory diseases.

2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.

Olsalazine-13C6 is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine (T20615) is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1

MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC50 of 25 nM and also demonstrates inhibition of thyroid peroxidase (TPO) with an IC50 of 2.2 μM. MPO-IN-4 has no effect on methyl guanine methyl transferase (MGMT) [1].

COX-2-IN-14 (compound 2a) is a highly potent and selective inhibitor of COX-2 (cyclooxygenase-2), binding strongly at the active site of the COX-2 co-crystal. Demonstrating remarkable in vivo anti-inflammatory activity, COX-2-IN-14 effectively reduces ear edema and myeloperoxidase (MPO) activity in mice [1].

MPO-IN-5 is a potent, irreversible inhibitor of MPO (myeloperoxidase). MPO-IN-5 inhibits MPO peroxidation (IC50: 0.22 μM) and hERG binding (IC50: 2.8 μM). 23000 M 1s 1.

Bivalirudin TFA is a hirudin analog and belongs to the class of specific, reversible direct thrombin inhibitors. Bivalirudin TFA exhibits high selectivity, with Ki values of 2.56 nM and 1.84 nM for α-thrombin and ζ-thrombin, respectively, and shows no significant activity against trypsin or γ-thrombin. Bivalirudin TFA also exhibits antiviral and anti-inflammatory activities. Bivalirudin TFA can be used in research on thrombotic diseases and other conditions.