mp10

MP-10 succinate is a potent and specific inhibitor of PDE10A.

Oleoylestrone (MP-101) is present in plasma and adipose tissue, has potential antioxidant effects, induces loss of body fat in rats, and can be used for weight loss.

CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.

MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.

MMP-9/10-IN-2 (compound 6e) serves as a potent inhibitor of MMP10 and MMP9, with an IC50 value for MMP10 at 0.076 μM and an inhibition concentration for MMP9 at 0.5 μM, achieving an inhibition rate of 93.18%. It plays a significant role in antitumor activities.

Acetrizoate sodium, known as the sodium salt of acetrizoic acid,can be used as a high-osmolality, water-soluble, iodinated radiographic contrast medium.

[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.

Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).Mardepodect hydrochloride up-regulates the expression of proteins encoding specific growth and transcription factors, cell signalling molecules and cell surface proteins. Mardepodect hydrochloride upregulates genes encoding specific growth factors, transcription factors, cell signalling molecules, and cell surface proteins, while downregulating a broad spectrum of cell cycle and apoptosis-related genes.

IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.