ml 116

ML116 is a potent and selective STAT3 inhibitor.

Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.

Chlorogenic acid is a natural phenol found in honeysuckle. Chlorogenic acid has a wide range of biological activities including anti-inflammatory, antioxidant, antitumor, antimicrobial, and neuroprotective.

Anticanceragent 260 (Compound 3g 4d) is an orally effective anticancer agent that inhibits the proliferation of cancer cells HCT-116, MIA-PaCa2, and MDA-MB231, with IC50 values of 98.7, 81.0, and 77.2 µg mL, respectively. It also promotes ulcer formation and lipid peroxidation, and exhibits anti-inflammatory and analgesic activities.

Curcuphenol in concentrations in the range of 29-116 µg ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner.

Verrucarin J (Muconomycin B), derived from the Myrothecium fungus family, effectively generates reactive oxygen species (ROS) to induce apoptosis in various cancer cell lines, including A549, HCT 116, and SW-620. Besides its anticancer properties, it exhibits antifungal activity against Candida albicans and Mucor miehei. Furthermore, it notably inhibits the arenavirus Junin (JUNV) yield with an IC 50 of 1.2 ng mL.

Rostratin A, a cytotoxic disulfide isolated from the marine-derived fungus Exserohilum rostratum, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an inhibitory concentration 50 (IC 50) value of 8.5 μg mL.

Rostratin B, a cytotoxic disulfide, exhibits in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC50 value of 1.9 μg mL.

Rostratin C, a cytotoxic disulfide, exhibits in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC50 value of 0.76 μg mL.

Diaporthein B, a highly oxidized pimarane diterpene, demonstrates significant activity against M. tuberculosis with a MIC of 3.1 μg mL and exhibits IC50 values ranging from 1.5-3 μM L against HCT 116 and LoVo colon cancer cells [1].