millettia

Toxicarol isoflavone, an iso avone, is extracted from Millettia brandisiana.

Robustic acid is a coumarin extracted from Millettia thonningii.

Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.

1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. 3. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. 4. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.

Colutehydroquinone is an antifungal isoflavonoid from Colutea arborescens.

Odoriflavene has antioxidant activity, and it also shows inhibition effects on the decrease of glutathione level of rat lens induced by UV irradiation. Odoriflavene shows cytotoxic activity against a SH-SY5Y cell line in vitro.

Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.

2',4',5'-Trimethoxy-2'',2''-dimethylpyrano[5'',6'':6,7]isoflavone is a natural product used in life sciences research. The catalog number is TN2708, and the CAS number is 211799-56-3.

Millewanin G shows antiestrogenic activity.

Millewanins H shows antiestrogenic activity.

SKLB050 is derived from the natural chalcone small molecule millepachine (MIL), which is extracted from the plant [Millettia pachycarpa]. SKLB050 exhibits potential antitumor activity both in vitro and in vivo. Biochemical and cellular assays indicate that SKLB050 binds directly and irreversibly to β-tubulin.

Kanjone is a compound discovered in Millettia peguensis, which can be used in the synthesis of protein tyrosine phosphatase 1B (protein tyrosinephosphatase1B) inhibitors. Kanjone holds potential for research in the fields of diabetes and neurological disorders.