methuosis

Methuosis inducer 1 is a potent methuosis inducer with anticancer activity.

DMBP is a VPS41 inhibitor that induces methuosis, a vacuolar form of cell death, in cancer cells and inhibits autophagy. It prevents the fusion of late lysosomes and autophagosomes with lysosomes. DMBP effectively suppresses metastasis in a metastatic melanoma mouse model and is applicable for melanoma research.

MOPIPP is a novel indolebased chalcone that can cross the blood-brain barrier. MOPIPP inhibits the tumor progression agaisnt glioblastoma cells. MOPIPP induces cellular vacuolization as well as increases autophagosomes numbers. MOPIPP also triggers methuosis and distrupts glucose uptake and glycolytic metabolism [1] [2] [3].

JH530 is a potent methuosis inducer that suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inducing complete intracellular vacuolization. It exhibits anti-tumor properties and is valuable for cancer research [1].