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Results for "

mammalian target of rapamycin

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    93
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    1
    TargetMol | Compound_Libraries
  • PROTAC Products
    1
    TargetMol | PROTAC
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    13
    TargetMol | Natural_Products
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    2
    TargetMol | Recombinant_Protein
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    5
    TargetMol | Antibody_Products
Rapamycin
Sirolimus, NSC-2260804, AY 22989
T153753123-88-9
Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
  • $30
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AZD-8055
T18591009298-09-2
AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.
  • $36
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MHY1485
T1908326914-06-1
MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, leading to accumulation of LC3II proteins and increased autophagosomes, thereby inhibiting cellular autophagy.
  • $43
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Torin 1
T60451222998-36-8
Torin 1 is an effective inhibitor of mTORC1 2 with (IC50: 2 nM 10 nM); has 1000-fold selectivity for mTOR than PI3K.
  • $30
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mTOR inhibitor-3
T121231207358-59-5In house
mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.
  • $55
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wye-132
WYE-125132, WYE125132, WYE 125132
T63461144068-46-1In house
WYE-125132 (WYE-132 (WYE-125132)) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
  • $39
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GDC-0349
RG-7603
T65101207360-89-1In house
GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.
  • $33
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way-600
WAY600
T67301062159-35-6In house
WAY-600 is a potent, ATP-competitive, and selective inhibitor of mTOR with an IC50 of 9 nM; it blocks mTORC1 P-S6K(T389) and mTORC2 P-AKT(S473) but not P-AKT(T308), and is selective for mTOR over PI3Kα (>100-fold) and PI3Kγ (>500-fold).
  • $32
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L-Leucine
Leu, (S)-Leucine
T3O274961-90-5
L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functions. L-Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. L-Leucine is available in many foods and deficiency is rare.
  • $42
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(+)-Usnic acid
D-Usnic Acid, (+)-Usniacin
T63547562-61-0
(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.
  • $29
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Vistusertib
AZD2014
T19611009298-59-2
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
  • $31
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ETP-46464
T20841345675-02-6
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
  • $34
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Dactolisib
NVP-BEZ235, BEZ235
T2235915019-65-7
Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR, with IC50 values of 4 nM for p110α, 5 nM for p110γ, 7 nM for p110δ, 75 nM for p110β, and 20.7 nM for mTOR.
  • $39
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PP121
T24151092788-83-4
PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , also inhibits DNA-PK (IC50: 60 nM).
  • $51
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XL388
T60301251156-08-7
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
  • $38
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torin 2
T61001223001-51-1
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM ATR DNA-PK inhibition is 28 nM 35 nM 118 nM, respectively.
  • $35
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pf-04691502
PF4691502
T62511013101-36-4
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
  • $30
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Everolimus
SDZ-RAD, RAD001
T1784159351-69-6
Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.
  • $37
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sapanisertib
TAK-228, MLN0128, INK 128
T18381224844-38-5
Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
  • $34
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omipalisib
GSK458, GSK2126458
T18611086062-66-9
Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.
  • $57
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Apitolisib
RG 7422, GNE 390, GDC-0980
T19161032754-93-0
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal cell carcinoma, and endometrial carcinoma, among others.
  • $38
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gedatolisib
PKI-587, PF-05212384
T19701197160-78-3
Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα γ (IC50: 0.4 5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K mTOR signaling pathway.
  • $45
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Temsirolimus
NSC 683864, CCI-779
T2145162635-04-3
Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.
  • $30
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gne-490
T223391033739-92-2
GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM).
  • $77
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TargetMol | Inhibitor Sale