m-36

p32 inhibitor M36 is an inhibitor of p32 mitochondrial protein. It binds directly to p32 and inhibits the p32 association with LyP-1.

LTURM-36 is a novel inhibitor of PI 3-kinase delta.

AM-36 is a potent Na+ channel blocker and antioxidant.

SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for research on acting as an immunological adjuv

M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.

Chlorotrianisene (Standard) is a reference standard for research and analysis in studies involving Chlorotrianisene. Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.

Norquetiapine (Standard) is a reference standard for research and analysis in studies involving Norquetiapine. Norquetiapine (N-Desalkylquetiapine) is a metabolite of Quetiapine and acts as a selective HCN1 channel inhibitor with an IC50 of 13.9 μM. It selectively inhibits norepinephrine reuptake and serves as a partial agonist at the 5-HT1A receptor (Ki = 45 nM). Norquetiapine also functions as an antagonist at presynaptic α2 (Ki = 237 nM), 5-HT2C (Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Additionally, it blocks human cardiac sodium channels Nav1.5 in a state-dependent manner. In LPS-injected C57BL/6 mice, Norquetiapine displays partial anti-inflammatory effects. This compound is utilized in research related to depression and inflammation.

Gimeracil (Standard) is a reference standard for research and analysis in studies involving Gimeracil. Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.

Tegafur (Standard) is a reference standard for research and analysis in studies involving Tegafur. Tegafur (FT 207) is a congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme.

Pretomanid (Standard) is a reference standard for research and analysis in studies involving Pretomanid. Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.

Safinamide (Standard) is a reference standard for research and analysis in studies involving Safinamide. Safinamide (FCE-26743) is a reversible and selective monoamine oxidase B (IC50 0.098μM) inhibitor, reducing the degradation of dopamine, and a glutamate release inhibitor (IC50 8μM). It also inhibits dopamine reuptake. Safinamide also blocks sodium and calcium channels. Potential additional uses of Safinamide might be Parkinson's disease, restless leg syndrome and epilepsy.

Ribostamycin sulfate (Standard) is a reference standard for research and analysis in studies involving Ribostamycin sulfate. Ribostamycin sulfate (Vistamycin sulfate) , an aminoglycoside antibiotic, contains a neutral sugar moiety and is produced by Streptomyces ribosome.

Netilmicin sulfate (Standard) is a reference standard for research and analysis in studies involving Netilmicin sulfate. Netilmicin sulfate (Netromycin) is an aminoglycoside antibiotic.

Isepamicin sulfate (Standard) is a reference standard for research and analysis in studies involving Isepamicin sulfate. Isepamicin sulfate (sch21420) Sulphate) , an aminoglycoside antibacterial with good activity against strains producing type I 6-acetyltransferase, inhibits bacterial protein synthesis by targeting the bacterial 30S ribosomal subunit.

Sisomicin Sulfate (Standard) is a reference standard for research and analysis in studies involving Sisomicin Sulfate. Sisomicin Sulfate (Pathomycin) is the sulfate salt form of sisomicin, a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. Sisomicin is structurally similar to gentamicin but has a unique unsaturated diamino sugar. Of the aminoglycoside antibiotics, sisomicin has the greatest activity against gram-positive bacteria.

Delamanid (Standard) is a reference standard for research and analysis in studies involving Delamanid. Delamanid (OPC-67683) is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall.

Mexiletine hydrochloride (Standard) is a reference standard for research and analysis in studies involving Mexiletine hydrochloride. Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myocardial cells, thereby reducing the rise rate of cardiac action potential (phase 0) and reducing the automaticity of Purkinje fibers.

4-Hydroxy Propranolol HCL (Standard) is a reference standard for research and analysis in studies involving 4-Hydroxy Propranolol HCL. 4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).

Norverapamil hydrochloride (Standard) is a reference standard for research and analysis in studies involving Norverapamil hydrochloride. Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

5-O-Desmethyl donepezil (Standard) is a reference standard for research and analysis in studies involving 5-O-Desmethyl donepezil. 5-O-Desmethyl donepezil is a metabolite of Donepezil that acts as an inhibitor of hERG channels, with an IC50 of 1.5 μM.

Mizoribine (Standard) is a reference standard for research and analysis in studies involving Mizoribine. Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.

Gatifloxacin hydrochloride (Standard) is a reference standard for research and analysis in studies involving Gatifloxacin hydrochloride. Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA rotase and topoisomerase IV.

Prilocaine (Standard) is a reference standard for research and analysis in studies involving Prilocaine. Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.

Sertindole (Standard) is a reference standard for research and analysis in studies involving Sertindole. Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)