long-chain polyunsaturated fatty acid

Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). Eicosapentaenoic Acid promotes DNA demethylation in the reexpression of the tumor suppressor gene CCAAT/ enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates the RAS/ERK/C/EBPβ pathway in U937 leukemia cells through demethylation of the CpG island of H-RAS intron 1. Eicosapentaenoic Acid promotes the relaxation of vascular smooth muscle cells and vasodilation.

Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic acid which has anti-inflammatory and anti-proliferative effects.

Eicosapentaenoyl-L-carnitine chloride is a long-chain acylcarnitine comprised of Eicosapentaenoic Acid and L-Carnitine. In a mouse model of myopia induced by defocus lenses, mice fed with diets rich in n-3/n-6 polyunsaturated fatty acids (PUFAs) showed increased levels of Eicosapentaenoyl-L-carnitine chloride in their eyes.

4(Z),7(Z),10(Z),13(Z),16(Z)-Nonadecapentaenoic acid is an unusual polyunsaturated fatty acid (PUFA) generated during the synthesis of docosahexaenoic acid-d5 . While the physiological properties of this compound are not known, dietary intake of n-3 long-chain PUFAs provides potential health benefits.

9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is an ω-3 very long-chain polyunsaturated fatty acid. It has been used to study the desaturation and elongation of ω-3 polyunsaturated fatty acids. It is elongated to form C26:5 or acted on by δ6 desaturase to form C24:6. 9(Z),12(Z),15(Z),18(Z),21(Z)-Tetracosapentaenoic acid is found at low levels in mouse brain and spleen and levels decrease in the brain and spleen of old and exceptionally old mice.

CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.

Eicosapentaenoic Acid (EPA) sodium, an orally active omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA), demonstrates a unique ability to demethylate DNA, thereby facilitating the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). This compound also activates the RAS/ERK/C/EBPβ pathway by demethylating H-Ras intron 1 CpG island in U937 leukemia cells and promotes the relaxation of vascular smooth muscle cells, leading to vasodilation.

12(Z),15(Z)-Heneicosadienoic acid, an ω-6 very long-chain polyunsaturated fatty acid, serves as a positional isomer of heneicosadienoic acid, which is scarcely found in living organisms.

Methyl all-cis-7,10,13,16,19-docosapentaenoate is an ester of a long-chain polyunsaturated ω-3 fatty acid.

Arachidic acid-d39 is the deuterated form of Arachidic acid. Arachidonic acid (Icosanoic acid) is a long-chain fatty acid found in all mammalian cells, typically esterified in membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids in human tissues.

Arachidic acid-d3 is the deuterated form of arachidic acid. Arachidonic acid (icosanoic acid) is a long-chain fatty acid present in all mammalian cells. It is commonly esterified into membrane phospholipids and is one of the most abundant polyunsaturated fatty acids in human tissues.

Arachidic acid-d2 is a deuterated form of Arachidic acid. Arachidonic acid (Icosanoic acid) is a long-chain fatty acid found in all mammalian cells, typically esterified into membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids in human tissues.

Arachidic acid-d4 is the deuterated form of Arachidic acid. Arachidonic acid (Icosanoic acid) is a long-chain fatty acid found in all mammalian cells, typically esterified in membrane phospholipids, and ranks among the most abundant polyunsaturated fatty acids in human tissues.

Arachidic Acid-D2 (Standard) is a reference standard of Arachidic Acid-D2 intended for quantitative analysis, quality control, and related biochemical research applications. Arachidic acid-d2 is a deuterated form of Arachidic acid. Arachidonic acid (Icosanoic acid) is a long-chain fatty acid found in all mammalian cells, typically esterified into membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids in human tissues.

Arachidic Acid-D3 (Standard) is a reference standard of Arachidic Acid-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Arachidic acid-d3 is the deuterated form of arachidic acid. Arachidonic acid (icosanoic acid) is a long-chain fatty acid present in all mammalian cells. It is commonly esterified into membrane phospholipids and is one of the most abundant polyunsaturated fatty acids in human tissues.

Arachidic Acid-D39 (Standard) is a reference standard of Arachidic Acid-D39 intended for quantitative analysis, quality control, and related biochemical research applications. Arachidic acid-d39 is the deuterated form of Arachidic acid. Arachidonic acid (Icosanoic acid) is a long-chain fatty acid found in all mammalian cells, typically esterified in membrane phospholipids, and is one of the most abundant polyunsaturated fatty acids in human tissues.

Arachidic Acid-D4 (Standard) is a reference standard of Arachidic Acid-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Arachidic acid-d4 is the deuterated form of Arachidic acid. Arachidonic acid (Icosanoic acid) is a long-chain fatty acid found in all mammalian cells, typically esterified in membrane phospholipids, and ranks among the most abundant polyunsaturated fatty acids in human tissues.

Very-long-chain polyunsaturated fatty acids (VLCPUFA) are crucial components of ceramides and sphingomyelins, found in the retina, sperm, and brain. The compound 14-cis-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA, with its specific biological functions remaining unclear. This VLCPUFA, along with others, has been studied for its potential in activating protein kinase C.

(±)14(15)-DiHETE is an oxidized lipid and a metabolite of Eicosapentaenoic Acid, which is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA).