lipase

Cetilistat (ATL-962) is a novel inhibitor of pancreatic lipase being developed by Alizyme for the treatment of obesity and associated co-morbidities, including type 2 diabetes.

HSL-IN-1 is an orally active and highly potent hormone-sensitive lipase (HSL) inhibitor that significantly reduces the reactive metabolite load and can reduce the release of free fatty acids from stored fat.

Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.

MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.

Lipase Substrate is a compound used to detect lipase activity (substrate).

Lipase, Candida antarctica, expressed in Aspergillus niger, is a serine hydrolase derived from the yeast Candida antarctica and expressed in the mold Aspergillus niger. It belongs to the α/β hydrolase fold family.

Lipase, Thermus flavus (EC 3.1.1.3), is an enzyme that catalyzes the chemical reaction: triacylglycerol + H₂O → diacylglycerol + carboxylate.

Lipase, Porcine (EC 3.1.1.3), is an enzyme that catalyzes the chemical reaction: triacylglycerol + H₂O = diacylglycerol + carboxylate.

Lipase, Thermus thermophilus (EC 3.1.1.3), is an enzyme that catalyzes the reaction: triglyceride + H₂O = diglyceride + carboxylate.

Lipase, Rhizopus oryzae (EC 3.1.1.3) is an enzyme that catalyzes the chemical reaction between triacylglycerol and water, resulting in diacylglycerol and a carboxylate.

Lipase, wheat germ (EC 3.1.1.3), is an enzyme that catalyzes the chemical reaction: triacylglycerol + H₂O = diacylglycerol + carboxylate.

Lipase, Rhizopus niveus (EC 3.1.1.3), is an enzyme that catalyzes the chemical reaction in which triglycerides and water (H₂O) are converted into diglycerides and carboxylate salts.

MAGL-IN-5 is a non-selective lipase inhibitor.

Atractylodin (Atractydin) has high lipase inhibitory activity (IC5:39.12 μM); Atractylodin possesses strong repellency activities against T. castaneum adults (LD50: 1.83 μg/cm). The repellency of Atractylodin (0.63 μg/cm) can achieve >90%.

LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.

RHC 80267 (U-57908) is a selective inhibitor of DAGL, with an IC50 of 4 μM in canine platelets.

Pancreatic lipase-IN-1 (compound 8) is an inhibitor of pancreatic lipase with a Ki value of 1.288 μM.

Pancreatic lipase-IN-2 (compound 7r) is a potent inhibitor of pancreatic lipase (PL), with an IC50 value of 2.67 μM, and exhibits anti-obesity effects.

Endothelial lipase inhibitor-1 is a potent inhibitor of endothelial lipase with an IC50 of 49 nM.

Lipase, triacylglycerol (Alkaline lipase) is a specific enzyme that plays an important role in the catabolism of triacylglycerol to glycerol and fatty acids and is required for the transfer of fatty acids to various tissues of the body, and whose transcriptional receipt of transcripts is subjected to nutrient/hormonal regulation and is capable of being upregulated by PPARγ,TNFα downregulation, and insulin-mediated downregulation of FOXO1 nuclear localization.

Monoacylglycerol lipase inhibitor 1, also known as compound 13 [1], is a potent inhibitor of monoacylglycerol lipase.

Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) with an IC50 of 2.13 μM and human carboxylesterase 1A (hCES1A) with an IC50 of 0.055 μM.

C. rugosa Lipase is an enzyme that acts as a biocatalyst, renowned for its regioselectivity in a variety of reactions such as transesterification, hydrolysis, and esterification.

Lipase, Pseudomonas fluorescens (Immobilized), derived from Pseudomonas fluorescens, demonstrates excellent applicability in the food industry for ester synthesis, biofuel production, and the synthesis of enantiomerically pure chiral pharmaceuticals.