lactate

Syrosingopine is a dual inhibitor of MCT1 and MCT4, 60 times more potent against MCT4, preventing lactate and H+ efflux. Syrosingopine is an orally available antihypertensive drug with potential for cancer research in combination with metformin.

Ethyl L-lactate, also known as L-lactic acid ethyl ester, is commonly used in biodegradable plastics and hand sanitizers, and is widely applied in biochemical experiments and drug synthesis research.

Squalamine lactate, an aminosterol compound discovered in the tissues of the dogfish shark, exhibits antimicrobial activity.

Magnesium lactate is a magnesium donor and buffering agent.

Trimethoprim lactate (NSC-106568 lactate) is an antibiotic that inhibits bacterial dihydrofolate reductase (DHFR). Trimethoprim lactate has demonstrated antimicrobial activity, with excellent inhibition of Gramnegative bacteria. Trimethoprim lactate is used alone for the Trimethoprim lactate is used alone or in combination with other antibiotics to treat a variety of eye, lung, and gastrointestinal infections.

Indole-3-lactate-O-β-D-glucopyranoside functions as an endogenous metabolite and serves as a plant growth regulator.

Ethyl p-hydroxyphenyllactate is a natural product of Crepis, Asteraceae. The catalog number is TN4021 and the CAS number is 62517-34-4. Ethyl p-hydroxyphenyllactate can be used as a reference standard.

Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the type II estrogen binding site (EBS)

Sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) is formed as a by-product of the formation of alpha-ketobutyrate via a reaction catalyzed by lactate dehydrogenase (LDH) or alpha-hydroxybutyrate dehydrogenase (alphaHBDH).

(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via lactate dehydrogenase. The D-form is derived from bacterial sources, while the L-form is endogenous. Phenyllactate levels are normally very low in blood or urine, but high levels indicate phenylketonuria (PKU) and hyperphenylalaninemia (HPA). PKU is due to a deficiency of phenylalanine hydroxylase (PAH), causing phenylalanine to convert to phenylpyruvic acid rather than tyrosine.

Isomalt (Palatinitol) is a mixture of 1,6-mannitol glucopyranoside and 1,6-sorbitol glucopyranoside

Lactic acid (2-hydroxypropanoic acid) is a product of glycolysis and is widely found in nature.Lactic acid is produced in the body during hypoxia in contracted skeletal muscle and can be removed under fully aerobic conditions.Lactic acid can be used as a hemodynamic indicator in critically ill patients.Lactic acid has antitumor activity.

Thevetiaflavone (2-Genistein-5-methyl ether) is a natural flavonoid from Wikstroemia indica that inhibits the leakage of lactate dehydrogenase from the cytoplasm and increases cell viability.

Tenuifoliside C, isolated from Polygala tenuifolia Willd, is a targeted lactate dehydrogenase inhibitor that significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1].

D-(-)-Lactic acid sodium (Sodium D-lactate) is a microbial metabolite and a chiral molecule commonly used in glycolysis-related studies. Among its isomers, the L-isomer is the most prevalent in biological systems.

Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice.

Glomeratose A, a lactate dehydrogenase inhibitor (LDH), [Compound BBX] is a small molecule that targets enzyme inhibitors (MJBB-_13798), effectively reducing lactate production in cells, thereby influencing metabolic processes and demonstrating potential therapeutic applications in conditions characterized by elevated lactate levels.

1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug.

Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.

Nigerose, a disaccharide identified in Acremonium, effectively maintains stability in HL-60 cells post-cryopreservation by preventing elevations in malondialdehyde (MDA) and reactive oxygen species (ROS) levels, and inhibiting lactate dehydrogenase (LDH) release, when administered at a 150 µM concentration alongside the glycoside salidroside.

Cucurbitacin D, a triterpenoid isolated from Ecballium elaterium (L.), exhibits anticancer and antitumor activity, inhibits glucose uptake and lactate production in metastatic PrC, and induces inflammasome activation independent of ERK1 2 activation. Cucurbitacin D, a novel inflammasome activator in macrophages, inhibits HepG2 cell proliferation and induces apoptosis by modulating the JAK STAT3, PI3K Akt mTOR and MAPK signaling pathways, and can be used in the study of cervical cancer, leukemia, and prostate cancer.

11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase

Iristectorin A, an isoflavone compound derived from Iris tectorum Maxim, is a lactate dehydrogenase inhibitor that is used in cancer research.

Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.