krüppel-like factor

CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.

ML264 (CID-51003603) is a selective kruppel-like factor 5 (KLF5) inhibitor, which potently Inhibits growth of Colorectal Cancer.

SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).

APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the KLF4 tumor suppressor.

SR18662, an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM, reduces the viability of multiple colorectal cancer cell lines and induces apoptosis.

DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects, inhibits cell proliferation and induces the expression of Krüppel-like Factor 4 (KLF4) and p21 in human colon cancer cells, inhibits Notch signaling, and can be used in the study of renal tubular adenomas.