japonicus

Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (Ophiogenin-3-O-alpha-L-rhaMnopyranosyl-(1->2)-beta-D-glucopyranoside) is a natural product with significant pharmacological effects on the cardiovascular system.

Petasites japonicus extract, derived from Petasites japonicus, possesses antioxidant, anti-inflammatory, anti-obesity, neuroprotective, and anticancer properties. It promotes osteoblast differentiation by upregulating Runx2 and Osterix in MC3T3-E1 cells.

Ophiopogonin C is a natural product isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside.

Leukotriene B4 (LTB4) is a compound derived from arachidonic acid via the 5-lipoxygenase pathway that mediates certain inflammatory and immune responses. Leukotriene B4 induces neutrophil extracellular traps that impede the clearance of Pneumocystis japonicus.

Neoxaline is an alkaloid isolated from fermentation broth of Aspergillus japonicus.

Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997). Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3 References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997).

Raddeanin A is a natural triterpenoid saponin from Cyperus japonicus that inhibits histone deacetylase and is also a potent immunogenic cell death inducer with strong anti-angiogenic and anti-tumor activities.

Cixiophiopogon A is a natural product from Ophiopogon japonicus.

14-Hydroxy sprengerinin C, a natural product derived from Ophiopogon japonicus.

Shizukaol G, a dimeric sesquiterpene, can be isolated from the roots of Chloranthus japonicus [1].

Shizukanolide, a sesquiterpene lactone extracted from Chloranthus japonicus (Chloranthaceae), has a dehydro derivative that exhibits moderate antifungal activity [1].

Preleoheterin (Compound 3), a labdane diterpene isolated from L. japonicus [1], exhibits anti-inflammatory properties by inhibiting the production of nitric oxide and pro-inflammatory cytokines in LPS-activated macrophages without inducing cytotoxicity at certain concentrations [2].

Ophiopogonone C (compound 3), an isoflavone, has been isolated from the ethanol extract of the tubers of Ophiopogon japonicus [1].

Ejaponine A (Compound 1), an insecticidal sesquiterpene ester derived from Euonymus japonicus, exhibits potent activity against Mythimna separata, with an LD50 of 89.2 μg g. It is employed for the control of this pest species [1].

6-Formyl-isoophiopogonanone B, a homoisoflavonoid, can be isolated from the species Ophiopogon japonicus [1].

Compound 24, also known as 6-Aldehydoisoophiopogonone B, is a homoisoflavonoid extractable from Ophiopogon japonicus [1].

Compound 1, (25R)-Ruscogenin-3-yl α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→4)]-β-D-glucopyranoside, is a steroidal saponin that can be isolated from the roots of Ophiopogon japonicus [1].

6-Aldehydoisoophiopogonanone A is a natural product from Ophiopogon japonicus.

Isoleojaponin is a natural product from Leonurus japonicus.

Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia reperfusion injury in liver transplantation.

Shizukaol A is a natural product from Chloranthus japonicus.

3,4-Dihydroxyallylbenzene 3,4-di-O-glucoside (1,2-Di-O-β-D-glucopyranosyl-4-allylbenzene) is a natural product found in the tuber of Ophiopogon japonicus Ker-Gawl.

Ginsenoside Rs2 is a natural product isolated from the leaves of Panax japonicus var..

11-oxo-alpha-amyrin (Neoilexonol) is a triterpene compound extracted from Leonurus japonicus (Lamiaceae) and is a natural compound .