infectious

(-)-β-pinene (Nopinene) is inhibit infectious bronchitis virus (IBV) with an IC50 of 1.32 mM,with antimicrobial activity

Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodulatory properties.

Glycerophospholipids, cephalins (Phosphatidylethanolamines (egg)) are a mixture of phosphatidylethanolamines isolated from eggs, with various fatty acyl groups at the sn-1 and sn-2 positions. Glycerophospholipids and cephalins can be completely hydrolyzed to obtain 1 mol of glycerol, phosphoric acid, ethanolamine and 2 mol of fatty acids. Phosphatidylethanolamines play a role in membrane fusion and disassembly of contractile rings during cell division, regulating membrane curvature. Phosphatidylethanolamines are able to transmit infectious prions without the help of any proteins or nucleic acids. One of the main roles of Phosphatidylethanolamines in bacterial membranes is to disperse the negative charges caused by anionic membrane phospholipids.

Lariciresinol is an enterolignan precursor, it possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious diseases in humans. Dietary lariciresinol

Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata. Andrograpanin has anti-inflammatory and anti-infectious properties.

Cinnabarin is an antibiotic obtained from Polystiotus cinnabarinus, P. versicolo, and Trametes cinnabarinus. It exhibits antibacterial activity against Gram-positive bacteria and demonstrates antiviral properties, making it a promising candidate for research in infectious diseases.

Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a penicillin that resists Penicillinase and exhibits antibacterial activity. It shows effective activity against Gram-positive cocci. Diphenicillin is promising for research on infectious diseases caused by Gram-positive bacteria such as staphylococci, pneumococci, and group A streptococci.

Eupolauridine is a selective DNA topoisomerase II inhibitor, exhibiting an IC50 of 20 μM against fungal topoisomerase I and 33 μM for human topoisomerase I. By inhibiting the catalytic activity of topoisomerase II, Eupolauridine stabilizes the enzyme's cleavage complex with DNA, resulting in DNA damage and imparting antifungal activity. [Eupolauridine] holds potential for the study of fungal infectious diseases.

Isofebrifugine is an alkaloid from the plant Changshan of the Saxifrage family with antimalarial and anti-infectious activity.

Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i

Derrone may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. It is also a novel Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.

2-C-Methyl-D-erythritol 4-phosphate is a unique metabolic intermediate exclusive to the non-mevalonate pathway (MEP) predominantly found in prokaryotes. It serves as a precursor for the synthesis of both isoprenoids and non-isoprenoids (including vitamins). Not present in humans, this compound represents a promising target for the development of bacterial-specific drugs for treating infectious diseases.

Albiducin A is an antibiotic discovered in Hymenoscyphus albidus, possessing both antibacterial and anticancer properties. Its minimum inhibitory concentration (MIC) against bacteria and fungi ranges from 16.7 to 66.7 mg/mL. The IC50 values for mouse fibroblasts (L929) and human cervical carcinoma cells (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A shows potential for research in the fields of infectious and cancer diseases.

Guanine-7-oxide (Guanine 7-N-oxide) is an antitumor antibiotic with antitumor and anti-Candida albicans activities. It inhibits the replication of viruses such as herpes virus, infectious hematopoietic necrosis virus (IHNV), and infectious pancreatic necrosis virus (IPNV). The compound also demonstrates significant activity against mouse L1210 leukemia cells.

Dotriacolide is a β-lactamase inhibitor with notable inhibitory activity against penicillinase and cephalosporinase, displaying ID50 values of 0.61 μg/mL and 0.15 μg/mL respectively. It holds potential for research in infectious diseases.