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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11428 | Glyco-Obeticholic acid | FXR | |
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR). | |||
T13092 | Tauro-Obeticholic acid | FXR | |
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR). | |||
T14326 | AS-35 | Others | |
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum. With IC50 values of 8 nM, 4 nM and 3 nM, respectively. It has antiallergi... | |||
TP1819L | Substance P 1-9 aceate | Neurotensin Receptor | |
Substance P 1-9 aceate is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder. | |||
T3A2467 | Allocryptopine | Thalictrimine,Fagarine I | Potassium Channel |
Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively. | |||
T3S2259 | Methyl eugenol | 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether | GABA Receptor |
1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its... | |||
T33449 | ML 1035 | ML103,ML-1035 | |
ML 1035 is a benzamide that elicits contractions from guinea-pig non-stimulated ileum. | |||
T12756 | ROS 234 dioxalate | Histamine Receptor | |
ROS 234 dioxalate is a potent antagonist of H3(pKB of 9.46 for Guinea-pig ileum H3-receptor) | |||
T23829 | Btm 1042 | Btm1042,Btm-1042 | |
Btm 1042 is an antispasmodic drug. It has been found to depress twitch responses in the ileum of guinea pigs. | |||
T70688 | S 0960 | ||
S 0960 is a dimeric bile acid analogue that acts as a specific inhibitor of the apical sodium-dependent bile salt transporter (ASBT) in the ileum. | |||
TN4812 | Pluviatolide | AChR | |
(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum. | |||
TN4713 | Onitisin | 5-HT Receptor | |
Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum. | |||
T27140 | Delequamine HCl | RS-15385,RS15385,RS 15385,Delequamine,RS-15385-197 | |
Delequamine HCl is a potent and selective alpha 2-adrenoceptor antagonist. Delequamine HCl has a pKi of 9.45 for alpha 2-adrenoceptors in the rat cortex (pA2 in the guinea-pig ileum of 9.72). | |||
T37494 | 11-trans Leukotriene E4 | 11-trans Leukotriene E4 | |
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum. | |||
T69126 | Clofeverine (free base) | ||
Clofeverine (free base) is a highly selective relaxant for gastrointestinal smooth muscles with a beta-receptor stimulative nature. On isolated ileum, the inhibitory effect of clofeverine for spontaneous motility was com... | |||
T71935 | WIN 66306 | ||
WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated g... | |||
T8437 | 3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox | Others | |
3-(4-prop-2-en-1-ylpiperazin-1-yl)quinox Antagonism to 2-methyl-5-HT induced contractions in guinea pig ileum | |||
T69324 | Clofeverine hydrochloride | ||
Clofeverine hydrochloride is the salt form of Clofeverine (free base), a highly selective relaxant for gastrointestinal smooth muscles with a beta-receptor stimulative nature. On isolated ileum, the inhibitory effect of ... | |||
T37492 | 11-trans Leukotriene C4 | 11-trans Leukotriene C4 | |
11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative... | |||
TP2075 | Bombinakinin M | ||
Potent bradykinin receptor agonist. Highly selective for mammalian arterial smooth muscle bradykinin receptors, displaying ~ 50-fold greater potency than bradykinin. Elicits dose-dependent contractile effects in smooth m... |