hyperproliferative

Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Amiprilose (SM 1213) has anti-inflammatory activity and inhibits the proliferation of a variety of hyperproliferative cell types.Amiprilose induces lymphokine-induced macrophage activation and may be used in studies of rheumatoid arthritis and psoriasis.

Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation, offering novel therapeutic approaches for treating skin hyperproliferative disorders.

S1PR-MO-1 is a modulator of sphingosine-1-phosphate receptor and is used to study hyperproliferative inflammatory diseases.

Protein kinase inhibitor 9 (Compound example 175) is an inhibitor of serine/threonine and tyrosine kinase activities. It can be utilized in research related to cancer, hyperproliferative diseases, rheumatoid arthritis, immune system disorders, transplant rejection, and inflammatory diseases.

Antimitotic agent-2 (Compound 1) is an antimitotic agent that inhibits the proliferation of human epidermal cells. It may be used in the treatment of hyperproliferative skin disorders.

KDM2B-IN-1 is a potent inhibitor designed specifically to target and inhibit the activity of histone demethylase KDM2B. This compound is ideal for conducting research related to hyperproliferative diseases.

PI3K-IN-27 is a potent inhibitor of PI3K, a family of lipid signaling kinases involved in cell growth, differentiation, migration, and apoptosis. It shows research potential in hyperproliferative diseases (e.g., cancer, inflammation) and in immune and autoimmune diseases.

TNKS1/2-IN-1 is a potent tankyrase (TNKS1/2) inhibitor with pIC50 values ranging from 7.1 to 8.2, used in research targeting cancer, fibrosis, and other hyperproliferative diseases.

12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX. It suppresses hyperproliferation and colony formation in Imiquimod-induced psoriatic keratinocytes, and reduces levels of reactive oxygen species, Ki67, IL-17A, TNF-α, and IL-6. This compound has utility in antipsoriatic research [1].