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(3)
By Target- Dehydrogenase
- ADC Cytotoxin(2)
- Antifolate(2)
- Apoptosis(2)
- DNA/RNA Synthesis(2)
- DHFR(1)
- NF-κB(1)
- Reactive Oxygen Species(1)
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Results for "
hdhfr(dihydrofolate reductase)
" in TargetMol Product Catalog- Inhibitors & Agonists4
- PROTAC Products1
Methotrexate
Cited
WR19039, NCI-C04671, CL14377, Amethopterin
T148559-05-2
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
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CitedCPS-11
CPS11, CPS 11, N-(Hydroxymethyl)thalidomide
T23911145945-21-7In house
CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line.
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Methotrexate disodium
T80037413-34-5
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
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Fanotaprim 
T366922120282-75-7
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor, suppressing the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM, a hDHFR IC50 of 308 ± 71 nM, and a hDHFR to TgDHFR selectivity ratio of 196.
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