harmane

Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.

Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenicity, co-mutagenicity and carcinogenicity.

Harmane-d is the deuterated form of Harmane. Harmane, a β-carboline alkaloid (BCA), acts as a potent neurotoxin, inducing marked tremors and psychiatric symptoms. It exhibits a high affinity for the I1 imidazoline receptor (IC50=30 nM), showing 1000 times more selectivity than for the α2-adrenergic receptor (IC50=18 μM). Additionally, Harmane is an efficient and selective monoamine oxidase inhibitor, with IC50 values of 0.5 μM and 5 μM for MAO A and B, respectively.

Harmane (Standard) is a reference standard for research and analysis in studies involving Harmane. Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.

Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.