gsmtx-4

GsMTx4 is a peptide inhibitor derived from spider venom that modulates mechanosensitive cation channels (MSCs), including stretch-activated channels (SACs) and certain TRP and Piezo-related channels. By inhibiting mechanosensitive channel activity, it has been shown in experimental models to reduce lysophosphatidylcholine-induced astrocyte toxicity and microglial reactivity, and is widely used as a pharmacological tool to study the physiological and pathological roles of mechanosensitive ion channels.

GsMTx4 TFA (1209500-46-8 free base) is a spider venom peptide that selectively inhibits cation permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.

D-GsMTx4 TFA belongs to natural products and is a TRPC1/6 and Piezo2 channel inhibitor with high selectivity and cell permeability, inhibiting Ca2+ influx and the mTOR pathway. This compound is used in research on myocardial infarction, chronic pain, and pulmonary fibrosis.

TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.