glucan synthase

Rezafungin (SP-3025) is a broad-spectrum and long-lasting echinocandin with potent antifungal activity against Candida, Aspergillus and Pneumocystis.

D75-4590 is a β-1,6-Glucan inhibitor. As glucan is a major component of the cell wall, specifically β-1,6-Glucan, D75-4590 can fight fungal infections by inhibiting its synthetase.

Anidulafungin (Ecalta) (LY303366) is an echinocandin derivative used as an antifungal drug. It inhibits glucan synthase activity.

Rezafungin acetate (Biafungin acetate) is a echinocandin with antimicrobial activity that inhibits 1,3-β-D-glucan synthase. It can be used for research on invasive fungal diseases in hematopoietic and bone marrow transplant recipients.

Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthase inhibitor with antifungal activity, disrupting fungal cell wall integrity, used in fungal infection research.

Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae, the inhibition of Candida albicans and the morphogenetic transformation of Candida albicans when treated. Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase. Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β−glucan by selective blockage of β(1→3) glucan synthase.

Caspofungin is a cyclic lipopeptide echinocandin and beta-(1,3)-D-glucan synthase inhibitor that is used to treat internal or systemic mycoses.

Enfumafungin, a triterpene glycoside extracted from Hormonema carpetanum fungus, acts as an antifungal by inhibiting (1,3)-beta-D-glucan synthase, crucial for fungal cell wall synthesis. It selectively targets yeasts and fungi, excluding Cryptococcus, without affecting Bacillus subtilis growth [1] [2].

Melittin free acid, a basic 26-amino-acid polypeptide, constitutes the primary active component of honeybee venom and serves as a phospholipase A2 (PLA2) activator. Exhibiting a broad-spectrum antifungal effect, it presents MIC values ranging from 0.4-60 μM. Its mechanism includes inducing cell apoptosis, inhibiting (1,3)-β-D-glucan synthase, and engaging in multiple pathways [1] [2].

Arborcandin D is a 1,3-β-glucan synthase inhibitor that functions as an antifungal antibiotic. It exhibits IC50 values of 3 μg mL against Candida albicans (C. albicans) and 0.35 μg mL against Aspergillus fumigatus (A. fumigatus). The minimum inhibitory concentration (MIC) of Arborcandin D for Candida species is 4 μg mL.

Arborcandin B is an inhibitor of 1,3-β-glucan synthase and serves as an antifungal antibiotic. The IC50 values of Arborcandin B for Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus) are 0.30 μg mL and 0.025 μg mL, respectively. The minimum inhibitory concentration (MIC) for Candida species is 2-4 μg mL.

Arborcandin F, a 1,3-β-glucan synthase inhibitor, serves as an antifungal antibiotic. It exhibits IC50 values of 0.012 μg mL against Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus). For Candida species, the minimum inhibitory concentration (MIC) of Arborcandin F ranges from 0.25 to 1 μg mL.

Arborcandin E is a 1,3-β-glucan synthase inhibitor used as an antifungal antibiotic. It exhibits IC50 values of 0.1 μg mL against Candida albicans (C. albicans) and 0.012 μg mL against Aspergillus fumigatus (A. fumigatus). Additionally, Arborcandin E has a MIC of 0.5-2 μg mL for Candida species.

Arborcandin A is a 1,3-β-glucan synthase inhibitor, acting as an antifungal antibiotic. It exhibits IC50 values of 0.25 μg mL against Candida albicans (C. albicans) and 0.05 μg mL against Aspergillus fumigatus (A. fumigatus). The MIC for the Candida species is 4-8 μg mL.

Arborcandin C is an inhibitor of 1,3-β-glucan synthase, functioning as an antifungal antibiotic. It exhibits IC50 values of 0.15 μg mL against Candida albicans (C. albicans) and 0.015 μg mL against Aspergillus fumigatus (A. fumigatus). The compound's minimum inhibitory concentration (MIC) for Candida species ranges from 1-2 μg mL.