glucan synthase

Rezafungin (SP-3025, Biafungin) is a natural product echinocandin and a 1,3-β-D-glucan synthase inhibitor with broad-spectrum antifungal activity, high tissue penetration, and a long half-life, used for the treatment of candidemia and invasive candidiasis.

D75-4590 is a β-1,6-Glucan inhibitor. As glucan is a major component of the cell wall, specifically β-1,6-Glucan, D75-4590 can fight fungal infections by inhibiting its synthetase.

Anidulafungin (Ecalta) (LY303366) is an echinocandin derivative used as an antifungal drug. It inhibits glucan synthase activity.

Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthase inhibitor with antifungal activity, disrupting fungal cell wall integrity, used in fungal infection research.

Rezafungin acetate (Biafungin acetate) is a echinocandin with antimicrobial activity that inhibits 1,3-β-D-glucan synthase. It can be used for research on invasive fungal diseases in hematopoietic and bone marrow transplant recipients.

Antifungalagent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with a minimum inhibitory concentration (MIC) of 7.5 μg/mL. It simultaneously inhibits chitin deacetylase (chitin deacetylase AngCDA) and 1,3-β-glucan synthase (1,3-β-glucan synthase). The compound functions by disrupting the integrity of the fungal cell wall and does not bind to ergosterol. Additionally, Antifungalagent 144 is useful in studying Aspergillus niger infections.

FR179642 is a key intermediate in the synthesis of the antifungal drug Micafungin and also corresponds to the cyclic peptide core structure of the lipopeptide natural product FR901379. FR179642 belongs to the structural framework of echinocandin-class antifungal compounds and serves as an important reference in the structural optimization and synthesis of β-1,3-glucan synthase inhibitors.

Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae, the inhibition of Candida albicans and the morphogenetic transformation of Candida albicans when treated. Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase. Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β−glucan by selective blockage of β(1→3) glucan synthase.

Ibrexafungerp citrate is a triterpenoid antifungal agent that inhibits the synthesis of 1,3-β-D-glucan in fungal cell walls, and although its functional outcome is similar to echinocandins, it binds to a distinct site on the glucan synthase enzyme, resulting in limited cross-resistance. Ibrexafungerp citrate exhibit concentration-dependent fungicidal activity against Candida species and retaining strong in vitro efficacy against the majority of fluconazole-resistant strains, supporting its use in antifungal resistance and drug development research.

Caspofungin is a cyclic lipopeptide echinocandin and beta-(1,3)-D-glucan synthase inhibitor that is used to treat internal or systemic mycoses.

Enfumafungin is a triterpenoid glycoside isolated from endophytic fungi, exhibiting antifungal activity against Candida and Aspergillus species by inhibiting (1,3)-β-D-glucan synthesis.

Melittin free acid, a basic 26-amino-acid polypeptide, constitutes the primary active component of honeybee venom and serves as a phospholipase A2 (PLA2) activator. Exhibiting a broad-spectrum antifungal effect, it presents MIC values ranging from 0.4-60 μM. Its mechanism includes inducing cell apoptosis, inhibiting (1,3)-β-D-glucan synthase, and engaging in multiple pathways [1] [2].

Caspofungin-D is the deuterated form of Caspofungin (T70350) diacetate. Caspofungin (T70350) (MK-0991) diacetate is a potent antifungal agent that inhibits the synthesis of 1,3-β-D-glucan synthase.

Caspofungin-D4 is a deuterium-labeled form of Caspofungin (T70350), an effective antifungal agent. It works by inhibiting the synthesis of 1,3-β-D-glucan synthase, a critical enzyme for fungal cell wall production.

Saricandin exhibits moderate antifungal activity. It inhibits glucan synthase with an ID50 of 242.0 μg/mL.

Fusacandin B inhibits (1,3)-β-glucan synthase and possesses antifungal properties.

Fusacandin A inhibits (1,3)-β-glucan synthase and exhibits antifungal properties.

Arborcandin D is a 1,3-β-glucan synthase inhibitor that functions as an antifungal antibiotic. It exhibits IC50 values of 3 μg/mL against Candida albicans (C. albicans) and 0.35 μg/mL against Aspergillus fumigatus (A. fumigatus). The minimum inhibitory concentration (MIC) of Arborcandin D for Candida species is 4 μg/mL.

Arborcandin B is an inhibitor of 1,3-β-glucan synthase and serves as an antifungal antibiotic. The IC50 values of Arborcandin B for Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus) are 0.30 μg/mL and 0.025 μg/mL, respectively. The minimum inhibitory concentration (MIC) for Candida species is 2-4 μg/mL.

Arborcandin F, a 1,3-β-glucan synthase inhibitor, serves as an antifungal antibiotic. It exhibits IC50 values of 0.012 μg/mL against Candida albicans (C. albicans) and Aspergillus fumigatus (A. fumigatus). For Candida species, the minimum inhibitory concentration (MIC) of Arborcandin F ranges from 0.25 to 1 μg/mL.

Arborcandin E is a 1,3-β-glucan synthase inhibitor used as an antifungal antibiotic. It exhibits IC50 values of 0.1 μg/mL against Candida albicans (C. albicans) and 0.012 μg/mL against Aspergillus fumigatus (A. fumigatus). Additionally, Arborcandin E has a MIC of 0.5-2 μg/mL for Candida species.

Arborcandin A is a 1,3-β-glucan synthase inhibitor, acting as an antifungal antibiotic. It exhibits IC50 values of 0.25 μg/mL against Candida albicans (C. albicans) and 0.05 μg/mL against Aspergillus fumigatus (A. fumigatus). The MIC for the Candida species is 4-8 μg/mL.

Arborcandin C is an inhibitor of 1,3-β-glucan synthase, functioning as an antifungal antibiotic. It exhibits IC50 values of 0.15 μg/mL against Candida albicans (C. albicans) and 0.015 μg/mL against Aspergillus fumigatus (A. fumigatus). The compound's minimum inhibitory concentration (MIC) for Candida species ranges from 1-2 μg/mL.