fdx1

Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.

Otenzepad (AF-DX 116) is a selective M2 mAChR antagonist with IC50 values of 386 nM in rat heart and 640 nM in rabbit peripheral lung.

Copper ionophore I is an efficient carrier of copper ions that modulates intracellular copper levels to induce cuproptosis, with effects observed in cells such as 4T1 (IC50= 0.45 μM) and MDA-MB-231 (IC50= 1.21 μM). It elevates ROS, leading to mitochondrial dysfunction, and decreases the expression of proteins FDX1, DLAT, and LIAS. Additionally, it can activate immune-related pathways, enhancing T cell infiltration, making it a valuable compound for cancer research.