e. coli β-glucuronidase

β-Glucuronidase-IN-1 is an E. coli β-glucuronidase (β-glucuronidase) inhibitor with a potent, selective, non-competitive, and orally active IC50 and Ki value of 283 nM and 164 nM, respectively, against E. coli β-glucuronidase.

EcGUS-IN-1 (Compound E-9) is a non-competitive inhibitor of β-glucuronidase, featuring an IC50 value of 2.68 μM and a Ki value of 1.64 μM. This compound effectively mitigates gastrointestinal adverse events (GIAE) associated with Escherichia coli infections by inhibiting the activity of E. coli β-glucuronidase.

β-Glucuronidase-IN-2 is a potent inhibitor of E. coli β-glucuronidase [IC50: 0.24 μM, Ki: 1.09 μM] and exhibits anti-proliferative effects with potential for anti-cancer and anti-inflammatory therapeutic studies.

3-Chlorogentisyl alcohol, characterized by its potent inhibitory action against E. coli β-glucuronidase with an IC(50) value of 0.74 µM and a K(i) value of 0.58 µM, demonstrates significant antiproliferative activity. This compound shows promise for use in the research of anti-cancer and anti-inflammatory therapies.