e 955

Sucralose is a non-nutritive artificial sweetener and sugar substitute that stimulates appetite in rodents by activating a conserved neural fasting response.

Sucralose (Standard) is the analytical standard of Sucralose, primarily used for research and analytical applications. Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Studies have demonstrated that Sucralose can activate conserved neuronal fasting responses, thereby exerting an appetite-stimulating effect in animal models such as rodents.

GNE-955 is a potent and orally active inhibitor of pan Pim kinase, with inhibition constants (Kis) of 0.018 nM, 0.11 nM, and 0.08 nM for Pim1, Pim2, and Pim3, respectively.