dht

5α-Dihydrotestosterone is an active tissue androgen that can be used to study desmoplasia-resistant prostate cancer.

DHT KLH is a coupling compound for immunological studies, consisting of dihydrotestosterone (DHT) antigen bound to a hemocyanin (KLH) adjuvant, a commonly used carrier protein that enhances the immunogenicity of the antigen. It is widely used to prepare specific antibodies for the study of androgen receptor-associated immune responses.

DHT BSA is an antigen-adjuvant conjugate of DHT (dihydrotestosterone) with bovine serum albumin (BSA). Conjugating the antigen to a protein adjuvant enhances the production of antigen-specific antibodies in vaccine models. The conjugate maintains protein folding without disrupting major epitopes, and it can improve cross-presentation and the generation of antigen-specific T cells.

CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).

Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) is a novel 5 alpha-reductase inhibitor.The antiprostatic effect of Isomer-Turosteride in adult rats is associated with the inhibition of the conversion of T to DHT.Isomer-Turosteride induces a decrease in prostate DHT independent of a secondary increase in T. Isomer-Turosteride has anticancer activity and inhibits the growth of tumor cells. Turosteride has anticancer activity and inhibits the growth of tumor cells. Translated with www.DeepL.com Translator (free version)

Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.

(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER.

NNGH is a matrix metalloproteinase 3 (MMP-3) inhibitor with anticancer activity that counteracts the inhibitory effects of E2 and DHT on RANKL membrane binding.

Neoaureothin, a bacterial metabolite found in Streptomyces, is an androgen receptor (AR) antagonist that inhibits dihydrotestosterone (DHT) binding to ARs (IC50 = 13 μM) and DHT-induced prostate-specific antigen expression in LNCaP cells (IC50 = 1.75 nM). It is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg ml, respectively), exhibits nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg ml), and increases survival of P. densiflora trees inoculated with B. xylophilus.

17,17-(Ethylenedioxy)androst-4-en-3-one (4-androstene-3,17-dione-17-cyclic ethylene ketal) is an effective ingredient in cosmetics, utilized in acne treatment and hair growth research. It inhibits reductase activity and prevents the binding of a receptor protein with 5α-DHT.

Cyprodinil, an anilinopyrimidine broad-spectrum fungicide, inhibits methionine biosynthesis in phytopathogenic fungi, effectively limiting cell growth of B. cinerea, P. herpotrichoides, and H. oryzae on amino acid-free media with IC 50 values of 0.44, 4.8, and 0.03 μM, respectively. Additionally, in the absence of the androgen receptor (AR) agonist DHT, Cyprodinil acts as an AR agonist (EC 50 =1.91 μM) and counters DHT's androgenic effects (IC 50 =15.1 μM).

1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).

Androgen receptor antagonist 4 (Compound AT2) exhibits anticancer activities by potently antagonizing AR transcriptional activity, inhibiting downstream AR target genes, and blocking DHT-induced nuclear translocation of AR. It is an antagonist of the androgen receptor (AR) with an IC50 of 0.15 μM [1].

Cioteronel is an antineoplastic compound with antiandrogenic activities. The antineoplastic action of CPC 10997 appears to be the inhibition of RNA synthesis in vitro. Although it blocks competitively the binding of dihydrotestosterone (DHT) to its protein receptor, it has no significant effects on either estrogen or progesterone receptors.

MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.

Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses. It has a feminizing effect on male pups and a virializing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning......

3α-Hydroxysteroid dehydrogenase (3α-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3α-hydroxy compounds. This enzyme significantly contributes to the inactivation of the androgen DHT by converting it into 3α-androstanediol, which exhibits reduced androgen activity. Such conversions are crucial in hirsutism research [1].

5α-Dihydrotestosterone-d4 is a deuterated compound of 5α-Dihydrotestosterone. 5α-Dihydrotestosterone has a CAS number of 521-18-6. Dihydrotestosterone is a potent androgenic metabolite of testosterone. It is an agonist of the androgen receptor.

Stanolone-d4 is a deuterated compound of Stanolone. Stanolone has a CAS number of 521-18-6. Dihydrotestosterone is a potent androgenic metabolite of testosterone. It is an agonist of the androgen receptor.