dermaseptin

Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.

Dermaseptin-B3 is an antimicrobial peptide that exhibits inhibitory effects against both Gram-positive and Gram-negative bacterial strains, with minimum inhibitory concentrations (MICs) of 1.3, 2.3, 5.0, 2.6, and 2.3 μM for S. aureus, P. aeruginosa, E. (ATCC 25922), and E. (54127) respectively. Additionally, this compound demonstrates antiproliferative activity against tumor cells [1] [2].

Dermaseptin-B9, an antimicrobial peptide, has been isolated from the Phyllomedusinae subfamily of frogs [1].

Dermaseptin-B5, an antimicrobial peptide sourced from the skin secretions of the South American frog Phyllomedusa bicolor, exhibits potent antimicrobial activity [1].

Dermaseptin-B4 is a potent antimicrobial peptide sourced from the skin secretions of the South American frog, Phyllomedusa bicolor [1].

Dermaseptin acetate, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration[1].

Adenoregulin (Dermaseptin b2), an antimicrobial peptide antibiotic, exhibits efficacy against both Gram-negative and Gram-positive bacteria, as well as yeast and fungi. Additionally, it augments the affinity of agonists for the A1 adenosine receptor [1].