dbco peg4 nhs ester

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

PC DBCO-PEG4-NHS ester, a PEG-based linker for PROTACs, connects two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Azido-PEG4-NHS-ester is a PEG-based linker molecule that can be used as a linker in PROTAC construction. It contains an azide group that participates in click chemistry reactions, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) with alkynes, as well as strain-promoted azide–alkyne cycloaddition (SPAAC) with DBCO or BCN groups, thereby enabling molecular conjugation.

DBCO-NHCO-PEG4-NHS ester is a DBCO-containing PEGylated active ester linker that combines NHS ester reactivity toward primary amines with strain-promoted azide-alkyne cycloaddition capability. It enables efficient bioconjugation through amide coupling and copper-free click reaction with azide groups. The PEG4 spacer provides hydrophilicity and tunable linker length, making it widely used in PROTAC and antibody-drug conjugate (ADC) construction.

DBCO-N-bis(PEG4-NHS ester) is a PEG linker equipped with one DBCO moiety and two PEG4-NHS esters. This compound serves as a versatile tool in click chemistry, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing molecules. It is commonly utilized for protein modification or labeling, making it a valuable reagent in biochemical applications.