dbco peg4 alkyne

DBCO-PEG4-alkyne is a four-unit PEG linker with non-cleavable properties, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions.

Azido-PEG4-acyl chloride is a PROTAC linker that falls under the PEG category, utilized in the synthesis of PROTAC molecules. As a click chemistry reagent, it contains an Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules bearing an Alkyne group. Additionally, it can partake in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Azido-C1-PEG4-C3-NH2 is a PROTAC linker within the PEG class, utilized in the synthesis of PROTAC molecules. Serving as a click chemistry reagent, it features an azide group capable of engaging in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Azido-PEG4-formylhydrazine-Boc is a PROTAC linker within the PEG category, suitable for PROTAC molecule synthesis. This compound serves as a click chemistry reagent, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules bearing DBCO or BCN groups.

Azido-PEG4-THP is a PEG-based PROTAC linker used for synthesizing PROTAC molecules. It functions as a click chemistry reagent, featuring an Azide group capable of engaging in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo a strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.

Azido-PEG4-Thiol is a PEG-based PROTAC linker used for synthesizing PROTAC molecules. As a click chemistry reagent, it possesses an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

DBCO-PEG4-GGFG-Dxd is a conjugate used in antibody-drug conjugates (ADCs) exhibiting potent antitumor activity. It incorporates Dxd, a DNA topoisomerase I inhibitor, connected through the cleavable linker DBCO-PEG4-GGFG [1]. This compound functions as a click chemistry reagent, featuring a DBCO group capable of strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.

Methyltetrazine-PEG4-hydrazone-DBCO, a cleavable 4-unit PEG ADC linker, serves as a click chemistry reagent in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules. It also includes a Tetrazine group capable of engaging in an inverse electron demand Diels-Alder reaction (iEDDA) with TCO-bearing molecules.

NH2-PEG4-hydrazone-DBCO serves as a cleavable 4-unit PEG ADC linker employed in the creation of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent features a DBCO group capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules bearing Azide groups.

Biotin-PEG4-SS-azide, a biotin-labeled ADC linker, is primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This compound serves as a click chemistry reagent featuring an Azide group, enabling it to partake in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Mal-PEG4-bis-PEG3-DBCO serves as a cleavable 7-unit PEG ADC linker in the creation of antibody-drug conjugates (ADCs) [1]. It functions as a click chemistry reagent, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with Azide-containing molecules.

Ald-Ph-PEG4-bis-PEG3-N3, a 6-unit cleavable PEG ADC linker, is used in the preparation of antibody-drug conjugates (ADCs) [1]. It serves as a click chemistry reagent featuring an Azide group, allowing it to engage in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain DBCO or BCN groups.

Amino-PEG4-bis-PEG3-N3, a cleavable 7-unit PEG ADC linker, is used in synthesizing antibody-drug conjugates (ADCs) [1]. As a click chemistry reagent, it contains an Azide group and can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Alkyne groups. Additionally, strain-promoted alkyne-azide cycloaddition (SPAAC) can occur with molecules containing DBCO or BCN groups.

DBCO-PEG4-HyNic, a cleavable 4-unit PEG ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1]. As a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

DBCO-PEG4-Propionic-Val-Cit-PAB is a click chemistry reagent and a cleavable 4-unit PEG ADC linker that incorporates a DBCO group. This group enables the compound to engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules. It is primarily utilized in the creation of antibody-drug conjugates (ADCs) [1].

N3-PEG4-amido-Lys(Fmoc)-acid is a 4 unit PEG ADC linker utilized in the production of antibody-drug conjugates (ADCs) [1]. This compound, functioning as a click chemistry reagent, is equipped with an Azide group that enables it to partake in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne group-bearing molecules. Additionally, it is capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester serves as a cleavable 4-unit PEG-based ADC linker in the formulation of antibody-drug conjugates (ADCs) [1]. This compound acts as a click chemistry agent featuring an Azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules equipped with DBCO or BCN groups.

DBCO-N-bis(PEG4-NHS ester) is a PEG linker equipped with one DBCO moiety and two PEG4-NHS esters. This compound serves as a versatile tool in click chemistry, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing molecules. It is commonly utilized for protein modification or labeling, making it a valuable reagent in biochemical applications.

Azide-PEG4-Desthiobiotin is a PEG derivative composed of desthiobiotin, four PEG units, and an azide group (azide). Biotin forms a stable non-covalent complex with Streptavidin. The azide group can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.