core

MUC1, mucin core is a type I transmembrane glycoprotein that is characterized by its overexpression and abnormal glycosylation in carcinoma cells. It specifically binds to domain 1 of ICAM-1.

The hepatitis B virus (HBV) core protein has been found in the nucleus, the cytoplasm, or both of HBV-infected hepatocytes. nuclear localization of the HBV core protein is negatively regulated by phosphorylation during the cell cycle.

HCV Core Protein (59-68) is a peptide containing residues 59-68 from the core protein of the Hepatitis C virus (HCV) [1].

HCV Core Protein (107-114), identified as the binding site within the region 101-118, is a minimally immunogenic fragment of the primary linear HCV core regions. This segment, comprising two residues that vary between genotypes I/II and III/VI, represents a potential focal point for the dissemination of HCV serotypes [1].

Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

Boc-LRR-AMC TFA is a fluorescent protease substrate used to detect the trypsin-like activity of the 26S proteasome or 20S proteasome core.

Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLE-AMC is typically used in cell lysates after experimental treatment.

Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. Z-LLL-AMC is typically used in cell lysates after experimental treatment.

OVA (329-337), a 9-aa core epitope (329–337) situated at the C-terminal end of the OVA peptide, embodies a specific sequence within the peptide structure.

PQDVKFP, a synthetic peptide, identifies antigenic domains within the core protein of the hepatitis C virus (HCV) [1].

HCV Peptide (35-44), a core protein of Hepatitis C Virus at positions 35 to 44, functions as an HLA-A2-restricted CTL epitope and inhibits NK cell activity through the KIR2DL2/3 receptor and synergistically through the CD94:NKG2A receptor [1].

HBV Seq1 aa:93-100 is a peptide fragment of the hepatitis B virus (HBV) core antigen spanning amino acids 93 to 100 [1].

HBV Seq1 aa:18-27 is a hepatitis B virus (HBV) core antigen peptide fragment spanning amino acids 18-27 [1].

α-Synuclein (61-95) (human) constitutes the hydrophobic core of α-synuclein and is implicated in inducing neuronal cell death. This segment is utilized in the study of neurodegenerative conditions such as Alzheimer's disease (AD) and Parkinson's disease (PD) [1] [2].

β-Amyloid(17-28) human is a fragment of the β-amyloid peptide (Abeta) associated with Alzheimer's disease (AD), promoting the aggregation of the full-length β-Amyloid40 into toxic aggregates [1]. This lipid-induced amyloid core segment is implicated in AD pathogenesis.

Dby HY Peptide (608-622), mouse, is a bioactive peptide with the sequence NAGFNSNRANSSRSS. As an HYAb epitope, it is derived from a gene family encoding for RNA helicases characterized by the DEAD (Asp-Glu-Ala-Asp) box motif. The Phenylalanine residue serves as an anchor, with FNSNRANSS as the probable core epitope.

Histone H4 (2-21) is a crucial core histone essential for the chromatinization of herpes simplex virus 1 (HSV-1) genomes.

matrix protein (3-15) [Zaire ebolavirus] is a peptide of the structural proteins linking the viral envelope with the zaire ebolavirus core. Ebola virus (EBOV) is a member of the family Filoviridae in the order Mononegavirales. It is the causative agent of

HBcAg (core antigen) is a hepatitis B viral protein. It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person.

Zebrafish Kisspeptin-1 acetate (1071873-79-4 Free base) comprises the core sequence of the zebrafish neuropeptide kisspeptin-1, regulating dopaminergic neurons in the zebrafish forebrain and fear responses.

TAT-CN21 is a potent and highly selective inhibitory peptide for CaMKII with an IC50 of 77 nM. This product achieves cell permeability through the TAT sequence (YGRKKRRQRRR), effectively blocking the catalytic activity of CaMKII and its interaction with the NMDA receptor subunit GluN2B. It plays a critical role in modulating excitotoxicity, reducing glutamate-induced neuronal damage, and serves as a core pharmacological tool for researching ischemic brain injury, neurodegenerative diseases, and synaptic plasticity.

LNSMGQD is a peptide that targets the adhesive interfaces of desmoglein (DSG1 and DSG3) core glycoproteins, interfering with the single peptide (SP) components of DSG trans-interactions. By binding to DSGs, LNSMGQD prevents the loss of DSG trans-interactions induced by autoantibodies, inhibits the activation of p38 MAPK, and prevents keratin filament retraction. It is useful for research into autoimmune skin diseases such as pemphigus vulgaris.