collagen

safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin levels, and fibrogenesis as judged by type I and type III collagen and laminin production. safironil had no effect on the size of liver granulomas without altering total hydroxyproline, but altered the pattern of fibrosis by increasing type III and decreasing type I collagen deposition.

L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.

Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.

Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.

Col003 is a selective and potent inhibitor of Hsp47, competitively binding to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It is useful for researching fibrosis.

cis-L-Hydroxyproline inhibits the synthesis and extracellular deposition of collagen. The growth inhibition of pancreatic cancer cells induced by the Hyp isomer could be due to endoplasmatic reticulum stress.

Collagen proline hydroxylase inhibitor-1 exhibits antifibroproliferative activity.

Collagen, Type I, from bovine achilles tendon is a type I collagen derived from bovine achilles tendon, which is widely found in marine invertebrate tissues. Collagen, Type I, from bovine achilles tendon is the only component of collagen fibers that make up the dermis, and plays a major role in bone and connective tissue. connective tissues, and functions primarily by forming and maintaining the integrity of the skeleton.

Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.

Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative that selectively inhibits collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Collagen-IN-1 reduces P-selectin expression, glycoprotein IIb IIIa activation, and the release of adenosine triphosphate and CD63 from platelets. This compound is promising for research into platelet-related thrombosis diseases [1].

Bovine Type II Collagen (Collagen Type II,Bovine) is a homologous superhelical structure consisting of three identical α1(II) chains, and is a major component of animal cartilage. Type II collagen has a variety of biological activities, including maintaining cartilage tissue integrity, inducing immune tolerance, and stimulating chondrocyte growth and redifferentiation.

Collagen, rat tail is a natural collagen from rat tail tendon, the main component is collagen type I. It can support cell attachment, proliferation and differentiation, and is commonly used in the preparation of cell culture substrates.

Anti-Human Mouse denatured collagen type-I Antibody (XL313) is an IgG1, κ inhibitor derived from mice, targeting denatured collagen type-I in both human and mouse.

Methacrylated Type I collagen (Col1MA) is a methacrylate-modified scaffold material used in tissue engineering, retaining the fundamental properties of natural collagen. In the presence of photoinitiator LAP, it self-assembles into a fibrous hydrogel, targeting bioactive adhesion sites to inherently support tissue cells and offer biodegradability. Applications include cell culture, bio 3D printing, and tissue engineering.

This is a peptide inhibitor of collagen fibrillar matrix assembly.

Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), ma

Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of type IV collagen and plays a role in angiogenesis.

Collagen Type II Fragment is a peptide with anti-inflammatory properties that effectively inhibits collagen-induced arthritis (CIA) in mice. It is useful for research focused on inflammation and immunity [1].

Recombinant Humanized Type III Collagen 28.6kDa is a synthesized form of humanized Type III collagen with a molecular weight of 28.6kDa. Known as rhCOLIII, it serves multiple biological functions, such as enhancing skin extracellular matrix regeneration and improving the cellular microenvironment. It inhibits the proliferation, migration, and invasion of breast cancer cells. Type III collagen is involved in cell adhesion, migration, proliferation, and differentiation through interactions with integrins.

Type III collagen (from bovine skin) is a collagen protein capable of stimulating the immune system in animals to generate specific antibodies against it. Additionally, this collagen serves as a hydrolytic substrate for matrix metalloproteinases (MMPs).

Type V collagen (from bovine amnion) is a highly purified form of collagen. It serves as an immunogen capable of inducing the production of specific antibodies in animals. Additionally, this collagen acts as a substrate for MMP hydrolysis.

Type IX collagen (from bovine articular cartilage) is a highly purified protein that can stimulate the immune system in animals to produce specific antibodies against this collagen. Additionally, collagen acts as a substrate for matrix metalloproteinases (MMP).

Type XI collagen (from bovine articular cartilage) is an immunization-grade collagen protein that induces the animal immune system to produce specific antibodies against it. Additionally, this collagen serves as a hydrolytic substrate for matrix metalloproteinases (MMP).