collagen

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is an IgG1, κ inhibitor derived from mice, targeting denatured collagen type-I in both human and mouse.

Glenzocimab (ACT017), a Fab fragment of a humanized anti-GPVI monoclonal antibody, demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model and has been studied in acute ischemic stroke and cerebral thrombosis.

NGM-438 is a humanized IgG1 monoclonal antibody targeting LAIR1. It reverses collagen-induced immunosuppression in myeloid cells and enhances anti-PD-1 monoclonal antibody-driven T-cell responses in immune cell-based functional assays.