Search Result

Search Results for " collagen "

Targets

138

Compounds

Natural Products

224

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T10861	Collagen proline hydroxylase inhibitor-1		Others
	Collagen proline hydroxylase inhibitor-1 exhibits antifibroproliferative activity.		Others
T80025	Bovine Type II Collagen	Collagen, Type II, Immunization Grade
	Type II collagen is a protein that demonstrates considerable effectiveness in alleviating pain and inflammation associated with collagen-induced arthritis in mice, with notable application in the treatment of osteoarthri...
T10862	Collagen proline hydroxylase inhibitor		Others
	Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents.		Others
TP2301	Type II collagen fragment		Others
	Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primar...		Others
TP1643	Alpha 1(I) Collagen (614-639), human
	This is a peptide inhibitor of collagen fibrillar matrix assembly.
TP2452	Collagen type IV alpha1 (531-543)	Hep III peptide,Gefyfdlrlkgdk
	Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of type IV collagen and plays...
T60303	Collagen-IN-1
	Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Coll...
T7692	2,4-DPD		HIF
	2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)		HIF
T2057	BVT 2733		Dehydrogenase
	BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.		Dehydrogenase
T16886	Sinefungin	Adenosyl-Ornithine,A-9145,Antibiotic 32232RP	Others , Histone Methyltransferase , Antibiotic , Antifungal
	Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates r...
T10860	Col003		HSP
	Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the investigation of fibrosis.		HSP
TP1328	TB500		Others
	TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4.		Others
T21616	L-006235	L 006235	Cysteine Protease
	L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.		Cysteine Protease
T11699	J-113863		CCR
	J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor...		CCR
T4283	SRI-011381		TGF-beta/Smad
	SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.		TGF-beta/Smad
T9195	SHR0302	ARQ252	Apoptosis , JAK
	SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).		Apoptosis , JAK
T6576	Malotilate	Malotilatum,NKK 105,Kantec	Lipoxygenase
	Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.		Lipoxygenase
T9138	Indirubin-3′-oxime	Indirubin-3'-monoxime	GSK-3 , CDK , JNK
	Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.		GSK-3 , CDK , JNK
TP1158	Copper tripeptide	GHK-Cu	Others , Endogenous Metabolite
	Copper tripeptide (GHK-Cu) is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. The tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found...		Others , Endogenous Metabolite
T5329	Trandolapril		Angiotensin-converting Enzyme (ACE)
	Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.		Angiotensin-converting Enzyme (ACE)
T5129	SRI-011381 hydrochloride	SRI-011381 hydrochloride [1629138-41-5(free base)]	TGF-beta/Smad
	SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.		TGF-beta/Smad
TD0098	Direct Red 80	Sirius Red,Sirius Red F 3BA,C.I. direct red 80	Others
	Direct Red 80 (Sirius Red) is a tetra azo dye. It can be used to detect amyloid and can magnify the usual birefringence of collagen fibers in tissue sections.		Others
T1606	Fasudil	HA-1077,AT877	ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
	Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T3060	Fasudil hydrochloride	Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877	ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy
	Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T23906	Collagenase inhibitor CI-2	SC 40827
	SC 40827 is a Collagenase inhibitor CI-2.
T3757	NQ301		Thrombin , Platelet aggregation
	NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).		Thrombin , Platelet aggregation
T15124	Diethyl-pythiDC		Others , Hydroxylase
	Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.		Others , Hydroxylase
T67961	Safironil		Others
	safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin le...		Others
T21653	1,4-DPCA		HIF/HIF Prolyl-Hydroxylase
	1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).		HIF/HIF Prolyl-Hydroxylase
T2386	Pirfenidone	S-7701,AMR-69,S-7701,AMR69	CCR , TGF-beta/Smad
	Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum...		CCR , TGF-beta/Smad
TP2365L	Acetyl tetrapeptide-9 Acetate	Acetyl tetrapeptide-9 Acetate(928006-50-2 Free base)	Others
	Acetyl tetrapeptide-9 Acetate plays a role in the stimulation of basement membrane polysaccharide (lumican) and the synthesis of collagen I.		Others
T8988	PythiDC		Others
	PythiDC is a selective collagen prolyl 4-hydroxylase inhibitor, neither causing general toxicity nor disrupting iron homeostasis.		Others
T15681	L-161982		Prostaglandin Receptor
	L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice.		Prostaglandin Receptor
TP2492	Hexapeptide-9 Acetate	Hexapeptide-9 Acetate(1228371-11-6 Free base)	Others
	Hexapeptide-9 Acetate, a Collagen peptide, helps strengthening structural tissues by naturally interacting with skin cells thereby promoting the rejuvenation process.		Others
T74030	MAHMA NONOate		Endogenous Metabolite , NO Synthase
	MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.		Endogenous Metabolite , NO Synthase
T5589	H-Gly-Pro-OH	Glycyl proline,Glycyl-L-proline	Endogenous Metabolite
	H-Gly-Pro-OH (Glycyl proline) is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism		Endogenous Metabolite
T38369	CAY10678		Prostaglandin Receptor , PD-1/PD-L1
	CAY10678 is an mPGES-1 inhibitor that inhibits PD-1.CAY10678 reduces collagen deposition and T-cell depletion, and may be used to study melanoma.CASHIPS		Prostaglandin Receptor , PD-1/PD-L1
T8855	Polydeoxyribonucleotide(Sodium salt)	Polydeoxyribonucleotide from salmon	Others
	Polydeoxyribonucleotide can improve secretion of various growth factors, promote collagen synthesis, and restore tensile strength of the Achilles tendon in a rat model with Achilles tendon injury.		Others
TP1156	H-Gly-Gly-Pro-OH	Glycyl-glycyl-L-proline	Others
	H-Gly-Gly-Pro-OH (Glycyl-glycyl-L-proline) is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism that is further cleaved by prolidase.		Others
T26917	BTT-3033	BTT3033,BTT 3033	Apoptosis , Integrin
	BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits platelet binding to collagen I and cell proliferation.BTT-3033 ...		Apoptosis , Integrin
T5286	Glycylglycine	Glycyl-glycine,Glycine dipeptide,Diglycocoll,Diglycine,Gly-gly,N-Glycylglycine	Others , Endogenous Metabolite
	Glycylglycine (Diglycine) is a dipeptide used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. Glycine is involved in the body's p...		Others , Endogenous Metabolite
TP2363L	Acetyl tetrapeptide-2 Acetate	Acetyl tetrapeptide-2 Acetate(757942-88-4 Free base)	Others
	Acetyl tetrapeptide-2 Acetate is most commonly used as a skin conditioner. Acetyl tetrapeptide-2 Acetate is done by compensating for hormone loss in the skin, especially collagen, providing somewhat of a plumping effect ...		Others
T77442	Glenzocimab	ACT017	Others
	Glenzocimab (ACT017) is a Fab fragment of a humanized anti-GPVI monoclonal antibody. Glenzocimab demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model. Glenzocimab has been studied ...		Others
TP2490	Palmitoyl Hexapeptide-12 Acetate	Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base)	Others
	Palmitoyl Hexapeptide-12 Acetate (Palmitoyl Hexapeptide-12 Acetate (171263-26-6 Free base)) can promote collagen, elastin, and hyaluronic acid on proliferation. It can be used to improve the skin's water content, increas...		Others
TP2308	TB500 acetate(885340-08-9 free base)	Frag17-23 Acetate,TB500 Acetate	Others
	TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) is a synthetic version of an active region of thymosin β4. It promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, col...		Others
T19389	L-Ascorbic acid 2-phosphate magnesium	2-Phospho-L-ascorbic acid magnesium	Phosphatase , Phosphorylase
	L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production.It is a long-acting vitamin C derivative that can stimulate...		Phosphatase , Phosphorylase
T24270	KS370G	KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide
	KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s...
T60438L	PXS-6302 hydrochloride	PXS-6302 hydrochloride （2584947-54-4 Free base）	Lipoxygenase
	PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS...		Lipoxygenase
T24816	SP-100030	SP100030,SP 100030	NF-κB
	SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ...		NF-κB
T8785	HALOFUGINONE LACTATE		DNA/RNA Synthesis , TGF-beta/Smad
	HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner ...		DNA/RNA Synthesis , TGF-beta/Smad

Compounds

Collagen proline hydroxylase inhibitor-1

T10861

Synonym:

Target: Others

Bovine Type II Collagen

T80025

Synonym: Collagen, Type II, Immunization Grade

Target:

Collagen proline hydroxylase inhibitor

T10862

Synonym:

Target: Others

type II collagen fragment

TP2301

Synonym:

Target: Others

Alpha 1(I) Collagen (614-639), human

TP1643

Synonym:

Target:

Collagen type IV alpha1 (531-543)

TP2452

Synonym: Hep III peptide,Gefyfdlrlkgdk

Target: Dehydrogenase

Sinefungin

T16886

Synonym: Adenosyl-Ornithine,A-9145,Antibiotic 32232RP

Target: Others, Histone Methyltransferase, Antibiotic, Antifungal

Target: Cysteine Protease

Target: TGF-beta/Smad

SHR0302

T9195

Synonym: ARQ252

Target: Apoptosis, JAK

Malotilate

T6576

Synonym: Malotilatum,NKK 105,Kantec

Target: Lipoxygenase

Indirubin-3′-oxime

T9138

Synonym: Indirubin-3'-monoxime

Target: GSK-3, CDK, JNK

Copper tripeptide

TP1158

Synonym: GHK-Cu

Target: Others, Endogenous Metabolite

Trandolapril

T5329

Synonym:

Target: Angiotensin-converting Enzyme (ACE)

SRI-011381 hydrochloride

T5129

Synonym: SRI-011381 hydrochloride [1629138-41-5(free base)]

Target: TGF-beta/Smad

Direct Red 80

TD0098

Synonym: Sirius Red,Sirius Red F 3BA,C.I. direct red 80

Target: Others

Fasudil

T1606

Synonym: HA-1077,AT877

Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy

Fasudil hydrochloride

T3060

Synonym: Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877

Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy

Collagenase inhibitor CI-2

Target: Thrombin, Platelet aggregation

Diethyl-pythiDC

T15124

Synonym:

Target: Others, Hydroxylase

Target: HIF/HIF Prolyl-Hydroxylase

Pirfenidone

T2386

Synonym: S-7701,AMR-69,S-7701,AMR69

Target: CCR, TGF-beta/Smad

Acetyl tetrapeptide-9 Acetate

TP2365L

Synonym: Acetyl tetrapeptide-9 Acetate(928006-50-2 Free base)

Target: Prostaglandin Receptor

Hexapeptide-9 Acetate

TP2492

Synonym: Hexapeptide-9 Acetate(1228371-11-6 Free base)

Target: Endogenous Metabolite, NO Synthase

H-Gly-Pro-OH

T5589

Synonym: Glycyl proline,Glycyl-L-proline

Target: Endogenous Metabolite

CAY10678

T38369

Synonym:

Target: Prostaglandin Receptor, PD-1/PD-L1

Polydeoxyribonucleotide(Sodium salt)

T8855

Synonym: Polydeoxyribonucleotide from salmon

Target: Others

H-Gly-Gly-Pro-OH

TP1156

Synonym: Glycyl-glycyl-L-proline

Target: Others

BTT-3033

T26917

Synonym: BTT3033,BTT 3033

Target: Apoptosis, Integrin

Glycylglycine

T5286

Synonym: Glycyl-glycine,Glycine dipeptide,Diglycocoll,Diglycine,Gly-gly,N-Glycylglycine

Target: Others, Endogenous Metabolite

Acetyl tetrapeptide-2 Acetate

TP2363L

Synonym: Acetyl tetrapeptide-2 Acetate(757942-88-4 Free base)

Palmitoyl Hexapeptide-12 Acetate

TP2490

Synonym: Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base)

Target: Others

TB500 acetate(885340-08-9 free base)

TP2308

Synonym: Frag17-23 Acetate,TB500 Acetate

Target: Others

L-Ascorbic acid 2-phosphate magnesium

T19389

Synonym: 2-Phospho-L-ascorbic acid magnesium

Target: Phosphatase, Phosphorylase

KS370G

T24270

Synonym: KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide

Target:

PXS-6302 hydrochloride

T60438L

Synonym: PXS-6302 hydrochloride （2584947-54-4 Free base）

Target: Lipoxygenase

SP-100030

T24816

Synonym: SP100030,SP 100030

Target: DNA/RNA Synthesis, TGF-beta/Smad

Cat No.	Product Name	Synonyms	Targets
T37512	Cis-4-Hydroxy-L-proline		Endogenous Metabolite
	cis-L-Hydroxyproline inhibits the synthesis and extracellular deposition of collagen. The growth inhibition of pancreatic cancer cells induced by the Hyp isomer could be due to endoplasmatic reticulum stress.		Endogenous Metabolite
T6856	Halofuginone	Tempostatin,empostatin,RU-19110	Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T3524	Halofuginone hydrobromide	Tempostatin,RU-19110 (hydrobromide),Stenorol	Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T5684	Ethyl 3,4-dihydroxybenzoate		Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
	Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T4454	Traumatic Acid	Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,Trans-2-Dodecenedioic Acid	Antioxidant
	Traumatic Acid (Dodec-2-Enedioic Acid) is a product of the hydroperoxide lyase pathway in plants. Potential as a wound healing agent that stimulates cell division near a wound site to form a protective callus.		Antioxidant
T0928	L-Ascorbic acid	Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate	Apoptosis , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite
	L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-...
T64812	Collagenase Type I	Collagenase I,Collagenase Type I (From microorganisms)	Others
	Collagenase Type I is a proteolytic enzyme that breaks down the peptide bonds in collagen, the main structural protein of connective tissue. Collagenase has been explored as a potential treatment option to break down her...		Others
T3S1944	Darutoside	Darutin	Others
	1. Darutoside (Darutin) can as an appropriate treatment for wounds. 2. Darutoside can improve skin elasticity, surface appearance and stretch mark removal, through soothing the skin, decreasing inflammation, restoring co...		Others
T2O2798	D-(+)-Trehalose	Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,Trehalose	Others , Endogenous Metabolite
	D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.		Others , Endogenous Metabolite
TN6975	Cirsiumaldehyde	5,5’-oxydimethylenebis(2-furfural)	Platelet aggregation
	Cirsiumaldehyde is a compound isolated from the mature fruits of Lobelia chinensis, Cornus officinalis, and the fruits of Hippophae rhamnoides.Cirsiumaldehyde in the presence of collagen inhibited U46619-induced (1~5 uM)...		Platelet aggregation
T3781	Jujuboside B		Others
	Jujuboside B has potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation, and also exhibits superior protection on the thromboembolic model.		Others
T5703	β,β-Dimethylacrylalkannin		Others
	β,β-Dimethylacrylalkannin is a natural product isolated from Arnebia nobilis Reichb.f, increases collagen and involucrin content in skin cells.		Others
TN6710	Methyl acetylsalicylate	ACETYLSALICYLIC ACID METHYL ESTER	Others
	Methyl acetylsalicylate (ACETYLSALICYLIC ACID METHYL ESTER) is a natural product isolated from Pisum sativum. Inhibition of collagen-induced human platelet rich plasma aggregation		Others
T5S0896	Loureirin A		Akt , PI3K
	Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept...		Akt , PI3K
TN2315	Xanthopurpurin		Platelet aggregation , Antifection
	Xanthopurpurin shows antiviral activity. Xanthopurpurin can effectively inhibit rotavirus multiplication by promoting virus-induced apoptosis in MA-104 cells. Xanthopurpurin shows mainly strong inhibition of collagen-ind...		Platelet aggregation , Antifection
TN3831	(-)-Denudatin B	Denudatin B	ATPase , Potassium Channel , Calcium Channel , PAFR
	(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin.		ATPase , Potassium Channel , Calcium Channel , PAFR
TN1507	Clematichinenoside AR		TNF , Autophagy
	Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis.		TNF , Autophagy
T2O2683	L-Proline	L-(-)-Proline,proline	Endogenous Metabolite
	L-Proline (proline) is a nonessential amino acid in humans. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles.		Endogenous Metabolite
T4S0498	Glaucocalyxin A	Wangzaozin B,Leukamenin F	Apoptosis , Akt , Caspase , PI3K
	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...		Apoptosis , Akt , Caspase , PI3K
TN1873	Lirinidine		Others
	(+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells; it also shows potent inhibition of melanogenesis. Lirinidine exhibits significant inhibition of collagen, a...		Others
T2769	3-Aminopropionitrile fumarate (2:1)	Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate	Others
	3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine.		Others
T4928	L-Kynurenine	(S)-Kynurenine	AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
	L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ...		AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
TN1254	3'-Methoxydaidzein		Sodium Channel
	3'-Methoxydaidzein is a dual isoflavone and Sodium Channel inhibitor. 3'-Methoxydaidzein inhibited NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM and 505 nM, respectively. 3'-Methoxydaidzein was specific for colla...		Sodium Channel
T2O2721	L-Cysteine	Thioserine,cysteine,L-(+)-Cysteine	Endogenous Metabolite
	L-Cysteine (L-(+)-Cysteine) is a non-essential sulfur-containing amino acid in humans. L-Cysteine is important for protein synthesis, detoxification, and diverse metabolic functions. Found in beta-keratin, the main prote...		Endogenous Metabolite
T4430	Isosaponarin		Others
	Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.		Others
TN6495	3,4-O-dimethylcedrusin
	3′,4-O-Dimethylcedrusin can improve wound healing in vivo by stimulating the formation of fibroblasts and collagen.
T19394	L-hydroxylysine dihydrochloride	(2S,5R)-5-Hydroxylysine dihydrochloride	Others
	L-hydroxylysine dihydrochloride , is formed by posttranslational hydroxylation of some lysine residues. It is an amino acid, is exclusive to collagen protein.		Others
T72798	Ganodermaones B
	Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .
TL0017	Aristolactam AIIIa		MAPK , CDK
	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of platelet aggregation induced by collagen or arachidonic acid.		MAPK , CDK
T31382	Deoxypyridinoline	Lysylpyridinoline
	Deoxypyridinoline is one of two pyridinium cross-links that provide structural stiffness to type I collagen found in bones. It is excreted unmetabolized in urine and is a specific marker of bone resorption and osteoclast...
TN5661	1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one
	1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one shows strong inhibition of collagen-induced, arachidonic acid-induced, and adenosine diphosphate-induced platelet aggregation of human whole blood.
TN3740	Cyclocommunol		PAFR
	Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong inhibition of arachidonic acid (AA)- and collagen-induced pla...		PAFR
TN5447	Apigenin 7-O-methylglucuronide	Apigenin-7-O-β-D-glucuronide methyl ester
	Apigenin 7-O-methylglucuronide did not affect GAG level or secretion, may potentially be used in osteogenesis imperfecta (OI) type I pharmacotherapy in patients with normal GAG content. Apigenin 7-O-methylglucuronide whi...
TN1310	6-Hydroxykaempferol 3,6-diglucoside		Others
	6-Hydroxykaempferol 3,6-di-O-glucoside and 6-hydroxykaempferol 3,6,7-tri-O-glucoside can inhibit platelet aggregation induced by collagen, they also show weak inhibitory effects on the adenosine 5'-diphosphate (ADP)- ind...		Others
TN1309	6-Hydroxykaempferol-3,6,7-triglucoside		Others
	6-Hydroxykaempferol 3,6,7-tri-O-glucoside and 6-hydroxykaempferol 3,6-di-O-glucoside can inhibit platelet aggregation induced by collagen, they also show weak inhibitory effects on the adenosine 5'-diphosphate (ADP)- ind...		Others
T79983	Flaccidoside II		Apoptosis
	Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral Nerve Sheath Tumors (MPNSTs) cell lines and ameliorates collagen-in...		Apoptosis
T36845	Isogarcinol
	Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppres...
TN4664	Norarmepavine		Others
	N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)-...		Others
TN4490	Manassantin B		ERK , BCL , p38 MAPK , TNF , NF-κB , JNK , STAT , Antifection
	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleu...
T37055	Cytostatin
	Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix. Cytostatin selectively inhibits protein Phosphatase 2A.
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Col...
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs =...

Natural Products

cis-4-Hydroxy-L-proline

T37512

Synonym:

Target: Endogenous Metabolite

Halofuginone

T6856

Synonym: Tempostatin,empostatin,RU-19110

Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Halofuginone hydrobromide

T3524

Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Ethyl 3,4-dihydroxybenzoate

T5684

Synonym:

Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy

Traumatic Acid

T4454

Synonym: Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,Trans-2-Dodecenedioic Acid

Target: Antioxidant

L-Ascorbic acid

T0928

Synonym: Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite

Collagenase Type I

T64812

Synonym: Collagenase I,Collagenase Type I (From microorganisms)

Synonym: Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,Trehalose

Target: Others, Endogenous Metabolite

Cirsiumaldehyde

TN6975

Synonym: 5,5’-oxydimethylenebis(2-furfural)

Target: Platelet aggregation

β,β-Dimethylacrylalkannin

T5703

Synonym:

Target: Others

Methyl acetylsalicylate

TN6710

Synonym: ACETYLSALICYLIC ACID METHYL ESTER

Target: Platelet aggregation, Antifection

(-)-Denudatin B

TN3831

Synonym: Denudatin B

Target: ATPase, Potassium Channel, Calcium Channel, PAFR

Clematichinenoside AR

TN1507

Synonym:

Target: TNF, Autophagy

L-Proline

T2O2683

Synonym: L-(-)-Proline,proline

Target: Endogenous Metabolite

Glaucocalyxin A

T4S0498

Synonym: Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

3-Aminopropionitrile fumarate (2:1)

T2769

Synonym: Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate

Target: Others

L-Kynurenine

T4928

Synonym: (S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

3'-Methoxydaidzein

TN1254

Synonym:

Target: Sodium Channel

L-Cysteine

T2O2721

Synonym: Thioserine,cysteine,L-(+)-Cysteine

Target: Endogenous Metabolite

3,4-O-dimethylcedrusin

TN6495

Synonym:

Target:

L-hydroxylysine dihydrochloride

T19394

Synonym: (2S,5R)-5-Hydroxylysine dihydrochloride

Synonym: Lysylpyridinoline

Target:

1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one

Apigenin 7-O-methylglucuronide

TN5447

Synonym: Apigenin-7-O-β-D-glucuronide methyl ester

Target:

6-Hydroxykaempferol 3,6-diglucoside

TN1310

Synonym:

Target: Others

6-Hydroxykaempferol-3,6,7-triglucoside

Target: ERK, BCL, p38 MAPK, TNF, NF-κB, JNK, STAT, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01132	COL6A3 Protein, Human, Recombinant	Human	HEK293

TMPY-01395	CTHRC1 Protein, Human, Recombinant (His)	Human	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-01860	Collagen II/COL2A1 Protein, Human, Recombinant (aa 1242-1487, His)	Human	HEK293
	COL2A1 is the alpha-1 chain of type II collagen which is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this protein are associated with achondrogenesis, chondrodysplasia, early o...
TMPY-05556	Adiponectin Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other t...
TMPY-02848	Adiponectin Protein, Human, Recombinant (hFc)	Human	HEK293
	Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other t...
TMPJ-00948	Endostatin Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑termi...
TMPY-03809	COL5A2 Protein, Human, Recombinant (mFc)	Human	HEK293
	COL5A2 is a component of type V collagen. It is known as the pro-alpha2(V) chain. COL5A2, together with two pro-alpha1(V) chains can form type V procollagen. These triple-stranded, rope-like procollagen molecules arrange...
TMPY-04164	COL6A3 Protein, Human, Recombinant (His)	Human	HEK293

TMPJ-00921	COL8A1 Protein, Human, Recombinant (His)	Human	Human Cells
	Collagen alpha-1(VIII) chain, also known as endothelial collagen, C3orf7 and COL8A1, can be cleaved into vastatin chain. COL8A1 is a short chain collagen and a major component of the basement membrane of the corneal endo...
TMPJ-00804	COL3A1 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Collagen alpha-1(III) chain（Col3a1） is a secreted protein and belongs to the fibrillar collagen family.It contains 1 fibrillar collagen NC1 domain and 1 VWFC domain. Collagen alpha-1(III) chain is a fibrillar collagen th...
TMPH-01113	COL8A1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	COL8A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPJ-01281	COL21A1 Protein, Human, Recombinant (His)	Human	Human Cells
	Collagen α-1(XXI) Chain (COL21A1) is a member of the fibril-associated collagens with interrupted helices (FACIT) family. COL21A1 is a secreted protein and contains six collagen-like domains, one TSP N-terminal (TSPN) do...
TMPY-03272	COL4A3 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	COL4A3 is a major structural component of basement membranes. It is composed of 3 alpha subunits, which are encoded by 6 different genes, alpha 1 through alpha 6. Each of these alpha subunits can form a triple helix s...
TMPY-04015	COL9A1 Protein, Human, Recombinant (mFc)	Human	HEK293

TMPH-01122	COL6A6 Protein, Human, Recombinant (His)	Human	E. coli
	COL6A6 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01111	COL4A1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	COL4A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-01120	COL4A2 Protein, Human, Recombinant (His)	Human	E. coli
	COL4A2 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01117	COL18A1 Protein, Human, Recombinant (GST)	Human	E. coli
	COL18A1 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPY-06826	CTHRC1 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-06775	CTHRC1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-04288	CTHRC1 Protein, Rat, Recombinant (His)	Rat	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPY-03960	COL9A1 Protein, Human, Recombinant (His)	Human	HEK293

TMPY-06795	CTHRC1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detec...
TMPH-02590	COL4A2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Canstatin, a cleavage product corr...
TMPH-01118	COL18A1 Protein, Human, Recombinant (His)	Human	Yeast
	COL18A1 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-01119	COL6A2 Protein, Human, Recombinant (GST & His & Myc)	Human	E. coli
	COL6A2 Protein, Human, Recombinant (GST & His & Myc) is expressed in E. coli.
TMPY-02596	GLT25D2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Glycosyl transferase 25 domain 2 (GLT25D2) is a glucosyltransferase enzyme expressed only at low levels in the nervous system. Glycosyltransferases are enzymes that act as a catalyst for the transfer of a monosaccharide ...
TMPH-01112	COL4A1 Protein, Human, Recombinant (GST)	Human	E. coli
	COL4A1 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-01115	COL15A1 Protein, Human, Recombinant (His)	Human	E. coli
	COL15A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02588	COL12A1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
TMPH-01114	COL12A1 Protein, Human, Recombinant (His)	Human	E. coli
	COL12A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02593	CTHRC1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May act as a negative regulator of collagen matrix deposition.
TMPH-02592	CTHRC1 Protein, Mouse, Recombinant (aa 33-245, His)	Mouse	HEK293
	May act as a negative regulator of collagen matrix deposition.
TMPH-02591	COL4A3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Tumstatin, a cleavage fragment cor...
TMPH-01123	CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc)	Human	HEK293
	CTHRC1 Protein, Human, Recombinant (aa 31-243, hFc) is expressed in HEK293.
TMPH-01121	COL4A3 Protein, Human, Recombinant (His)	Human	E. coli
	COL4A3 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02589	COL26A1 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus
	COL26A1 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus.
TMPY-03266	COL4A3BP Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	COL4A3BP is a member of the StarD2 subfamily. It contains a pleckstrin homology domain at its amino terminus and a START domain towards the end of the molecule. COL4A3BP has a lipid-binding domain that mediates intrac...
TMPY-01681	Adiponectin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other t...
TMPJ-00605	GPVI Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Glycoprotein VI (GPVI) is a 63 kDa platelet/megakaryocyte-specific type I transmembrane glycoprotein of the immunoglobulin superfamily that is an important collagen receptor and initiator of platelet activation, aggregat...
TMPH-01116	COL17A1 Protein, Human, Recombinant (His)	Human	E. coli
	COL17A1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-00292	CD36 Protein, Human, Recombinant (hFc)	Human	Human Cells
	Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ...
TMPH-00219	Adiponectin Protein, Bovine, Recombinant (His)	Bovine	Yeast
	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the l...
TMPH-00350	Adiponectin Protein, Feline, Recombinant	Feline	E. coli

TMPJ-00995	Serpin H1 Protein, Human, Recombinant (His)	Human	Human Cells
	Serpin H1 is a serine proteinase inhibitors Which belongs to the serpin family. Serpin H1 is induced by heat shock. Serpin H1 localizes to the endoplasmic reticulum lumen and binds specifically to collagen. Thus it is th...
TMPH-02342	Collagenase Protein, Hypoderma lineatum, Recombinant (His & Myc)	Hypoderma lineatum	E. coli
	This enzyme is a serine protease capable of degrading the native triple helix of collagen. Also cleaves the B chain of insulin at the 15-Leu-\|-Try-16 and 22-Arg-\|-Gly-23 bonds. Hydrolyzes casein, but not Px-Pro-Leu-Gly-P...
TMPH-00419	Microbial collagenase Protein, Clostridium perfringens, Recombinant (His & Myc)	Clostridium perfringens	E. coli
	Microbial collagenase Protein, Clostridium perfringens, Recombinant (His & Myc) is expressed in E. coli.
TMPY-01009	TGFBI Protein, Human, Recombinant (His)	Human	HEK293
	TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several ...
TMPJ-01172	IL-17 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque...
TMPH-00010	MMP-14 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tiss...
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