click-3

Tris(benzyltriazolylmethyl)amine (TBTA) is a tertiary amine with three 1,2,3-triazole groups that complexes with and stabilizes copper(I), thereby accelerating azide-alkyne cycloadditions used in click chemistry.

DBCO acid 2 is a Click Chemistry intermidate used for antibody-drug conjugates.

PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker conjugate utilized in PAC, comprising the BRD4 degrader GNE-987 connected with a 3-PEG linker. This compound serves as a click chemistry reagent, featuring an Azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing an Alkyne group. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules that possess DBCO or BCN groups.

H-(Gly)3-Lys(N3)-OH is a chemical reagent featuring an azide group prominently used in click chemistry for coupling with alkyne-containing fragments. Azides are extensively utilized for this purpose due to their effectiveness in such reactions. A polyglycine segment containing up to seven glycine residues has been reported to bind to surfaces, demonstrating potential applications in nanostructures; specifically, the Gly7-NHCH2 peptide segment binds to mica surfaces in aqueous solutions.

(2R,3S)-Fmoc-Abu(3-N3)-OH is a click chemistry reagent that contains an azido group.

(2S,3S)-H-Abu(3-N3)-OH (hydrochloride) is a click chemistry reagent containing an azide group. This compound can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that contain an alkyne group. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules featuring DBCO or BCN groups.

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. 20(S)-hydroxy Cholesterol (20(S)-OHC) is an oxysterol which binds SMO and activates hedgehog signaling (EC50 = 3 μM), and this activation is selective for the nat-20(S)-OHC enantiomer. Nat-20(S)-OHC synergizes with the SMO agonist SAG, suggesting an allosteric effect. Nat-20(S)-yne is a form of nat-20(S)-OHC with a terminal alkyne group, which can be used in linking reactions known as click chemistry. Click chemistry involves highly dependable and specific azide-alkyne bioconjugation reactions and can be used to capture or immobilize bioactive molecules. Thus, nat-20(S)-yne has been conjugated with magnetic beads to demonstrate that nat-20(S)-OHC directly binds SMO.

SCO-PEG3-NH2, a cleavable ADC linker with 3 PEG units, serves as a copper-free click chemical reagent for catalyst-free click reactions.

SCO-PEG7-Maleimide, a cleavable ADC linker with 3 PEG units, serves as a copper-free click chemical reagent for catalyst-free click reactions. Its maleimide group (-Maleimide) degrades in aqueous media and has applications in drug delivery studies.

Palmitoleic acid alkyne, an ω-terminal alkyne derivative of palmitoleic acid, facilitates click chemistry applications. This compound has played a crucial role in examining protein palmitoylation processes. Specifically, the cis form of palmitoleic acid alkyne selectively tags wild-type Wnt3a protein within mouse fibroblast L-cells expressing Wnt3a and its secretion in conditioned media, distinguishing itself from the trans form and proving ineffective against the S209A mutant Wnt3a.

Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH). Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells. DYn-2 consists of 1,3-cyclohexanedione coupled to an alkyne moiety by a 3-carbon spacer. The cyclohexanedione group selectively reacts with protein sulfenic acid modifications. The alkyne group of DYn-2 can then be detected using azide-bearing tags by standard click chemistry. This approach offers superior sensitivity relative to using azide-modified probes with alkynyl detection tags.

DBCO-PEG3-propionic EVCit-PAB is a 3-unit PEG ADC linker utilized in the production of antibody-drug conjugates (ADCs) [1]. As a click chemistry reagent, this compound features a DBCO group designed for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.

Mal-bis-PEG3-DBCO, a cleavable three-unit PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent features a DBCO group that engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.

DBCO-PEG3 acetic-EVCit-PAB, a cleavable 3-unit PEG ADC linker, plays a crucial role in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound features a DBCO group, enabling it to engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, and is also utilized as a click chemistry reagent.

TCO-PEG3-aldehyde, a cleavable 3-unit PEG ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

SCO-PEG2-Maleimide, an ADC Linker with three PEG units, serves as a copper-free click chemical reagent suitable for catalyst-free click reactions. This compound's maleimide group (-Maleimide) is susceptible to degradation in aqueous media, and it has found applications in drug delivery studies.

(2S,3R)-H-Abu(3-N3)-OH (hydrochloride) is a click chemistry reagent containing an azide group. This compound can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) with molecules that possess an alkyne group. Additionally, it is capable of engaging in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules that have DBCO or BCN groups.

H-L-Tyr(3-N3)-OH is a click chemistry reagent containing an azide group. This compound enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that have an alkyne group. It can also undergo strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Boc-L-Tyr(PEG(3)-N3)-OH is an azide-containing click chemistry reagent.

3-Azido-D-alanine, a derivative of azido D-alanine (D-alanine), is utilized in click chemistry for labeling purposes.

H-(Gly)3-Lys(N3)-OH (hydrochloride) is a click chemistry reagent renowned for its high yield, specificity, and simplicity, making it an ideal choice for creating bindings among nucleic acids, lipids, proteins, and other molecules across various research domains.

Palmitoyl alkyne-coenzyme A (palmitoyl alkyne-CoA), a thioester formed from ω-alkynylated palmitic acid and CoA, serves as a chemical reporter for the labeling of palmitoylated proteins through click chemistry. This process utilizes probes such as biotin-azide or 3-azido-7-hydroxycoumarin for both in vitro and in vivo studies.

3-Azidopropanol, a click chemistry reagent featuring an azide group, holds significant potential for facilitating bindings among nucleic acids, lipids, proteins, and various molecules. Its application across numerous research domains stems from advantageous traits like high yield, specificity, and simplicity [1].

3-Azidopropylamine, a click chemistry reagent characterized by its azide group, facilitates the complexation and transfection of plasmid DNA by reacting with the starch sugar present in potato starch [1].