cellcyclearrest

Ginsenoside C-K (Ginsenoside K) is a bacterial metabolite of G-Rb1 exhibiting anti-inflammatory effects by reducing iNOS and COX-2.

Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucose-metabolizing enzymes, promotes glucose homeostasis. Kaempferitrin exerts immunostimulatory effects on immune responses mediated by splenocytes, macrophages, PBMC and NK cells. Kaempferitrin induces cytotoxic effects to include: cell cycle arrest in G1 phase and apoptosis via the intrinsic pathway in a caspase-dependent pathway.

Gracillin can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent. Gracillin can be selected as lead compounds for the development of new drugs against I. multifiliis.

Schinifoline is a quinolone derivative extracted from Zanthoxylum schinifolium Sieb with cytotoxic activity that promotes radiosensitization of cancer cells, affects the cell cycle and apoptosis.

2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG) is a natural and stable vitamin C analog that induces apoptosis and cell cycle arrest in cancer cells by stabilizing p53 protein.

S)-(-)-Perillic acid is a terpenoid natural product capable of inhibiting protein pentosylisation and protein acylation. It exhibits anti-infective and anti-cancer activity, inducing cell cycle arrest and apoptosis in non-small cell lung cancer cells while increasing intracellular protein levels of Bax, p21, and caspase-3.

Glychionide A is a flavonoid glycoside discovered in Glycyrrhiza glabra that exhibits antitumor activity against PANC-1 cells by inducing autophagy, apoptosis, cell cycle arrest, and disruption of mitochondrial membrane potential.

Gypenoside LI is a natural product with anticancer activity that generates ROS, downregulates procaspase-8 and MMP-2/9, inhibits Wnt/β-catenin signaling, and induces cell cycle arrest and apoptosis.

Picrasidine Q is an anticancer natural alkaloid that targets FGFR2, inducing apoptosis and G1 arrest in oesophageal squamous cell carcinoma (ESCC) cells.